PMID: 3746600Aug 1, 1986Paper

Castleman's disease in children

Journal of Pediatric Surgery
R W PowellW L Marsh

Abstract

A three and one-half-year-old girl and a 12-year-old boy presented with features of the two clinical presentations of Castleman's disease or giant lymph node hyperplasia. The girl presented with anemia, fever, night sweats, hypergammaglobulinemia, and a palpable abdominal mass. Her symptoms were consistent with those seen in the plasma-cell type of this disease. The boy presented with acute appendicitis and a left hilar mass was noted on his chest radiograph. His asymptomatic presentation was typical of the hyaline-vascular form. Both patients are well without evidence of recurrence four years following resection. Castleman's disease is a benign disorder of lymph nodes that occurs rarely in children. Since the original report in 1954 we could find only 18 cases in the 16-year and younger age group and our patient with the symptomatic form represents the youngest patient reported in the English literature. The management requires surgical resection of the enlarged nodes both for diagnosis and therapy since the enlarged nodes can mimic malignant tumors of the lymphoid system. No recurrences have been reported in pediatric patients.

References

Jan 1, 1978·AJR. American Journal of Roentgenology·D G NordstromH B Latourette
Aug 1, 1975·The Journal of Pediatrics·J S Miller, J J Miller
Jul 1, 1956·Cancer·B CASTLEMANV P MENENDEZ

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Citations

Sep 17, 2011·Surgery Today·Mitsuhiko OhtaTeruyoshi Ishida
Sep 5, 1998·Pediatric Clinics of North America·C S Kelly, R E Kelly
Nov 20, 1998·Journal of Pediatric Gastroenterology and Nutrition·M D RodefeldJ C Langer
Jun 9, 2005·World Journal of Surgical Oncology·Pascal BucherPhilippe Morel
Nov 1, 1995·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·K L Taylor, R O Kaschula
May 1, 1995·Journal of Pediatric Surgery·V J ShroffC W Wesselhoeft
Dec 3, 2014·Pediatric Transplantation·Tamara O ThomasAngela Lorts
Jun 12, 2004·ANZ Journal of Surgery·Benjamin P C WeiGeorge Alex
Jan 1, 1990·Leukemia & Lymphoma·A Yabuhara, A Komiyama
Nov 4, 1998·Journal of Clinical Ultrasound : JCU·K KonnoO Masamune
Nov 5, 2020·Auto- Immunity Highlights·Sami AlhoulaibyHisham Qalaani

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