Castration fails to prevent prenatally programmed hypertension in male rats.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Lori L WoodsJohn A Resko

Abstract

Male offspring of rats that were modestly protein restricted during pregnancy become hypertensive as adults, whereas their female littermates remain normotensive. The purpose of this study was to determine the role of testosterone in promoting this sexual dimorphism of prenatally programmed hypertension. Rats were fed either a normal (19% protein, NP) or modestly protein-restricted (8.5% protein, LP) diet throughout pregnancy. Male offspring either remained intact or were castrated (CAS) at 30 days of age. Female offspring remained intact. At approximately 22 wk of age, the offspring were chronically instrumented for measurement of mean arterial pressure and renal function. Intact male LP offspring were hypertensive compared with male NP offspring (138 +/- 2 vs. 130 +/- 2 mmHg, P < 0.007), whereas female LP offspring were normotensive (123 +/- 1 vs. 122 +/- 2 mmHg in NP females). In CAS males, blood pressure in both diet groups was not different from that in intact males of the same group (138 +/- 3 mmHg in LP CAS males, and 131 +/- 2 mmHg in NP CAS males). Glomerular filtration rate and effective renal plasma flow were also not significantly affected by castration. However, castration significantly reduced protein excretion in...Continue Reading

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Citations

Oct 13, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Umberto SimeoniFarid Boubred
Nov 26, 2013·Acta Physiologica·N B OjedaB T Alexander
Jan 16, 2016·The Journal of Endocrinology·Chiung-Kuei HuangChawnshang Chang
Feb 18, 2017·International Journal of Molecular Sciences·You-Lin Tain, Chien-Ning Hsu
Oct 20, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Baojian XueAlan Kim Johnson
Jan 28, 2016·Clinical Science·John Henry Dasinger, Barbara T Alexander
Mar 4, 2014·Physiology·Suttira IntapadBarbara T Alexander
Mar 24, 2020·Sexual Medicine·Omer Faruk KirlangicSerap Gur

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