Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhage

Journal of Applied Physiology
S MayrM K Angele

Abstract

Several studies indicate that cell-mediated immune responses, i.e., macrophage (MPhi) cytokine release capacities, myosin heavy chain (MHC) class II (Ia) expression, etc., are suppressed after trauma-hemorrhage in male mice. Testosterone has been shown to be responsible for the depression of MPhi cytokine responses in males after trauma-hemorrhage. Antigen presentation via MHC class II plays a key role in initiating and maintaining cell-mediated and humoral immune responses. It remains unknown, however, whether testosterone has any effect on MHC class II after trauma-hemorrhage. To study this, male C3H/HeN mice were castrated or sham castrated 2 wk before trauma (midline laparotomy) and hemorrhage (Hem; blood pressure 35 +/- 5 mmHg for 90 min and resuscitation) or sham operation. Four hours thereafter, MHC class II (Ia) expression was measured using flow cytometry. The results indicate that MHC class II (Ia) expression on peritoneal and splenic MPhi was significantly suppressed in male mice after trauma-hemorrhage. Prior castration, however, prevented the depression in MHC class II (Ia) expression on peritoneal and splenic MPhi after trauma-hemorrhage. Castration did not affect MHC class II (Ia) expression in MPhi from sham-cas...Continue Reading

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Citations

Dec 20, 2012·The American Journal of Tropical Medicine and Hygiene·Mizuki SasakiHiromi Ikadai
Jun 18, 2015·Expert Opinion on Therapeutic Targets·Maximilian WenigerIrshad H Chaudry
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May 19, 2021·Biology of Sex Differences·Carlos L Correa-MartínezStefanie Kampmeier

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