Castration triggers growth of previously static androgen-independent lesions in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model

The Prostate
Mac A JohnsonBlake Lee Neubauer

Abstract

Androgen-deprivation remains the standard of care for metastatic prostate cancer, yet its total impact on the course of disease is incompletely established. We have examined the long-term effects of castration upon the progression of established cancer in the TRAMP transgenic mouse model of prostate cancer. Mice castrated at 15-weeks of age, as well as intact littermates, were followed until spontaneous death from cancer. Statistical analyses of age-at-death versus primary tumor mass revealed that mice segregate into two categories of response to androgen-deprivation. In Category One, the act of castration paradoxically triggers the growth of microscopic androgen-independent lesions, as evidenced by a statistical synchronization of primary tumor growth. Delaying castration until 20-weeks of age delays the synchronized growth of these tumors, as well as the deaths of the host mice. In Category Two, castration eliminates or substantially delays primary tumor growth, but fails to eliminate metastases. so that castration is found to impart no long-term survival advantage. We propose a two-step model for the alteration of androgen signaling in prostate cancer capable of explaining the above paradoxical results, which is based upon t...Continue Reading

References

Jan 1, 1978·The Journal of Urology·W J Catalona, W W Scott
Apr 1, 1984·European Journal of Cancer & Clinical Oncology·M E HarperK Griffiths
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·N M GreenbergJ M Rosen
Aug 21, 1996·Journal of the National Cancer Institute·P H GannM J Stampfer
Dec 10, 1997·American Journal of Clinical Oncology·M RibeiroG Falkson
Jul 29, 1998·The Journal of Urology·L R MillerP C Walsh
Jun 11, 1999·The Urologic Clinics of North America·J T Isaacs
Feb 9, 2000·Radiologic Clinics of North America·S W Hayward, G R Cunha
Jul 25, 2000·The Prostate·G SchatzlS Madersbacher
Oct 2, 2001·CA: a Cancer Journal for Clinicians·R T GreenleeM Thun
Jul 11, 2002·The Lancet Oncology·Herman Adlercreutz
Jul 12, 2002·The Urologic Clinics of North America·Badrinath R Konety, Robert H Getzenberg
Aug 3, 2002·Oncogene·Laurie Jackson-Grusby
Oct 19, 2002·The Prostate·Ping L ZhangGlenn Bubley
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·J R GingrichN M Greenberg
Apr 15, 2003·The Prostate·Paula J Kaplan-LefkoNorman M Greenberg
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Aug 12, 1950·Journal of the American Medical Association·R M NESBIT, W C BAUM
Jul 1, 1946·The Journal of Urology·S A VEST, T H FRAZIER

❮ Previous
Next ❯

Citations

Apr 29, 2009·Asian Journal of Andrology·Zai-Xian ZhangXiao-Feng Wang
Nov 22, 2007·Neoplasia : an International Journal for Oncology Research·Wendy J HussGary J Smith
Oct 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Diane M RobinsOrla A O'Mahony
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yao TangArif Hussain
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christoph S ZornMark L Day
Nov 18, 2008·Molecular Cancer Research : MCR·Orla A O'MahonyDiane M Robins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Norman M GreenbergJ M Rosen
Proceedings of the National Academy of Sciences of the United States of America
B Kwabi-AddoMichael M Ittmann
© 2021 Meta ULC. All rights reserved