Castroviejo Lecture 2009: 40 years in search of the perfect contact lens.

Cornea
H Dwight CavanaghJames V Jester

Abstract

To identify the pathophysiological changes produced by contact lens wear that predispose the cornea to infection and search for prospective modifiable risk factors that could reduce the incidence of this critical complication in millions of patients worldwide. Significant experimental and clinical publications are reviewed, and the results of ongoing studies are presented. Pseudomonas aeruginosa (PA) is the most common pathogen causing lens-related infectious keratitis over 3 decades. Contact lens wear can increase the risk of infection by increasing surface cell PA binding, thereby promoting invasion between broken tight junctions and initiating direct intracellular invasion mediated by lens-induced membrane lipid rafts. Prevention of upregulation of specific surface-binding receptors for PA with concomitant increase in infection risk is a zero damage game where independent interactions among lens type, mode of wear, oxygen transmissibility, polymer, and toxic effects of associated care solutions ideally should collectively produce no increased ability for PA to attach and/or to invade, thus minimizing the risk for lens-associated infections. The specific hypothesis tested is, "no increased epithelial surface damage... no incr...Continue Reading

References

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Feb 26, 2003·Investigative Ophthalmology & Visual Science·Patrick M LadageH Dwight Cavanagh
Aug 1, 2006·Investigative Ophthalmology & Visual Science·Naoka YamamotoH Dwight Cavanagh
Jul 17, 2007·Eye & Contact Lens·Gowri PachigollaH Dwight Cavanagh
Jan 4, 2008·Investigative Ophthalmology & Visual Science·Danielle M RobertsonH Dwight Cavanagh
Jan 9, 2008·Eye & Contact Lens·Masaki ImayasuH Dwight Cavanagh
Jun 10, 2008·Ophthalmology·Fiona StapletonBrien A Holden
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Sep 16, 2009·Emerging Infectious Diseases·Jennifer R VeraniUNKNOWN AcanthamoebaKeratitis Investigation Team

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Citations

Mar 1, 2012·Eye & Contact Lens·Danielle M RobertsonH Dwight Cavanagh
May 1, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Mark W Swanson
Apr 15, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kazuki TajimaHiroshi Goto
Apr 16, 2013·The Ocular Surface·Srihari NarayananAlison M McDermott
Jan 29, 2016·BMC Ophthalmology·Kyung-Sun NaChoun-Ki Joo
Jan 13, 2015·Journal of Optometry·Alex MuntzLyndon Jones
Sep 9, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kazuki TajimaHiroshi Goto
Sep 21, 2016·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Deborah JonesPhilip Morgan
Apr 12, 2017·Scientific Reports·Danielle M RobertsonMeifang Zhu
Jan 5, 2019·Eye & Contact Lens·Ömür Uçakhan, Mehtap Arslanturk-Eren
Nov 22, 2019·Journal of Medical Microbiology·Yasmin HilliamCraig Winstanley
Dec 7, 2019·Biomedizinische Technik. Biomedical Engineering·Katharina HoenesMartin Hessling
Sep 10, 2020·International Journal of Environmental Research and Public Health·Katharina HoenesMartin Hessling
Apr 21, 2021·Eye & Contact Lens·Brittany PerziaVishal Jhanji

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