PMID: 8598056Mar 1, 1996Paper

catA, a new Aspergillus nidulans gene encoding a developmentally regulated catalase

Current Genetics
R E NavarroJ Aguirre

Abstract

Aspergillus nidulans asexual sporulation (conidiation) is a model system for studying gene regulation and development. The CAN5 cDNA is one of several clones isolated based on transcript induction during conidiation. Here we present the molecular characterization of its corresponding gene, demonstrating that it encodes a developmentally regulated catalase, designated catA. The catA 744-amino-acid-residue polypeptide shows significant identity to other catalases. Its similarity to prokaryotic catalases is greater than to other fungal catalases. catA mRNA is barely detectable in growing mycelia, highly induced during sporulation, and present in isolated spores. However, catA expression is not dependent on the developmental regulatory genes brlA, abaA and wetA. Direct catalase activity determination in native gels revealed the existence of two bands of activity. One of these bands represented the major activity during vegetative growth and was induced during sporulation. The second catalase activity appeared after the induction of sporulation and was the predominant activity in spores. Disruption of catA abolished the major spore catalase without eliminating the vegetative activity, indicating the existence of at least two catalas...Continue Reading

Citations

Dec 4, 2004·Molecular Genetics and Genomics : MGG·B LeuthnerP H Schreier
Dec 1, 2001·Free Radical Biology & Medicine·A DíazW Hansberg
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