PMID: 9001663Dec 1, 1996Paper

Catabolic effect in premature infants with early dexamethasone treatment

Acta Paediatrica
F J TsaiT F Yeh

Abstract

To evaluate the catabolic effects of dexamethasone therapy on protein metabolism, amino acid concentrations and urinary 3-methylhistidine (3MH) were measured in 28 premature infants who were included in a double-blind controlled study using early dexamethasone therapy in the prevention of bronchopulmonary dysplasia. Fifteen infants received dexamethasone (0.5 mg/kg/day i.v.) and 13 infants received normal saline as control. Heparinized venous blood samples for amino acid analysis were obtained before the study and again at day 5 after starting the study. Urinary 3MH was measured on days 1, 3, 5, 7, 14, 21, and 28 of treatment. A substantial increase in amino acid concentrations was observed in infants receiving dexamethasone. Alanine, glutamine, citrulline, ornithine and cystine concentrations increased twofold or more. The 3MH:creatinine ratio was increased in the treated group. These metabolic effects were most likely due to an increase in protein catabolism.

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Citations

Aug 11, 2004·The Journal of Nutritional Biochemistry·Guoyao WuJ Marc Rhoads
Jan 11, 2001·The New England Journal of Medicine·A R StarkUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Apr 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·W E Ward, S A Atkinson
Feb 22, 2012·Clinics in Perinatology·Kristi Watterberg
Feb 26, 2000·Clinics in Perinatology·H M Farrag, R M Cowett
Feb 26, 2000·Clinics in Perinatology·P J Thureen, W W Hay
Oct 28, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Shujiro FujitaYoshihiro Ishikawa

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