Catabolism of polyamines

Amino Acids
Nikolaus Seiler

Abstract

Owing to the establishment of cells and transgenic animals which either lack or over-express acetylCoA:spermidine N(1)-acetyltransferase a major progress was made in our understanding of the role of polyamine acetylation. Cloning of polyamine oxidases of mammalian cell origin revealed the existence of several enzymes with different substrate and molecular properties. One appears to be identical with the polyamine oxidase that was postulated to catalyse the conversion of spermidine to putrescine within the interconversion cycle. The other oxidases are presumably spermine oxidases, because they prefer free spermine to its acetyl derivatives as substrate. Transgenic mice and cells which lack spermine synthase revealed that spermine is not of vital importance for the mammalian organism, but its transformation into spermidine is a vitally important reaction, since in the absence of active polyamine oxidase, spermine accumulates in blood and causes lethal toxic effects. Numerous metabolites of putrescine, spermidine and spermine, which are presumably the result of diamine oxidase-catalysed oxidative deaminations, are known as normal constituents of organs of vertebrates and of urine. Reasons for the apparent contradiction that spermi...Continue Reading

Citations

May 10, 2011·Applied Microbiology and Biotechnology·Jens Schneider, Volker F Wendisch
Jun 10, 2010·Plant Cell Reports·Yoshihiro TakahashiTomonobu Kusano
Jul 3, 2008·Planta·T KusanoY Takahashi
May 22, 2007·Amino Acids·R MontañezM A Medina
Jul 5, 2007·Amino Acids·P ChavesF Sánchez-Jiménez
Dec 17, 2009·Amino Acids·Merja R HäkkinenTuomo A Keinänen
Aug 3, 2011·Amino Acids·Manuela CervelliPaolo Mariottini
Aug 4, 2011·Amino Acids·Oscar Perez-Leal, Salim Merali
Sep 27, 2006·Pituitary·Joseph E Ippolito
May 23, 2007·Biochemistry·Subray S HegdeJohn S Blanchard
Dec 17, 2009·Biochemistry·Mariya S AdachiPaul F Fitzpatrick
Nov 15, 2013·Chemical Research in Toxicology·Anthony E Pegg
Nov 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·David J Lefer
May 30, 2008·The Journal of Biological Chemistry·Andrés J López-ContrerasRafael Peñafiel
Feb 18, 2011·Critical Reviews in Food Science and Nutrition·Preeti SinghHorst-Christian Langowski
Aug 13, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ljerka Prester
Nov 18, 2010·Journal of Experimental Botany·Paola FincatoParaskevi Tavladoraki
Aug 6, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alessandra F PernaNatale G De Santo
Jan 1, 1997·Annual Review of Physiology·C G Nichols, A N Lopatin
Nov 18, 2011·Lipids in Health and Disease·Paul L WoodDayan B Goodenowe
Aug 7, 2013·Indian Journal of Dermatology·Valentina BroshtilovaLjubka Miteva
Jul 10, 2013·Amino Acids·Alice PasiniEmanuele Giordano
Apr 24, 2014·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Taibo LiuTomonobu Kusano
Mar 19, 2013·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Saleh UmairHeather V Simpson
Feb 20, 2014·Journal of Experimental Botany·Abdellah AhouParaskevi Tavladoraki
Mar 5, 2014·Plant & Cell Physiology·Miki Fujita, Kazuo Shinozaki

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