Catalase activity in cerebellum, hippocampus, frontal cortex and striatum after status epilepticus induced by pilocarpine in Wistar rats

Neuroscience Letters
R M FreitasM M F Fonteles

Abstract

The mechanism underlying the vulnerability of the brain to status epilepticus (SE) induced by pilocarpine remains unknown. Oxidative stress has been implicated in a variety of acute and chronic neurologic conditions, including SE. The present study was aimed at was investigating the changes in catalase activity after pilocarpine-induced seizures and SE. The Control group was treated with 0.9% saline (NaCl, subcutaneously (s.c.)) and sacrificed 1h after the treatment. Another group was treated with pilocarpine (400 mg/kg, s.c., Pilocarpine group) and sacrificed 1h after treatment. The catalase activity in the cerebellum, hippocampus, frontal cortex and striatum of Wistar rats was determined. The results have shown that pilocarpine administration and resulting SE produced a significant increase in the catalase activity in the hippocampus (36%), striatum (31%) and frontal cortex (15%) of treated adult rats. Nevertheless, in the adult rat cerebellum after SE induced by pilocarpine no change was observed in the catalase activity. Our results demonstrated a direct evidence of an increase in the activity of the scavenging enzyme (catalase) in different cerebral structures during seizure activity that could be responsible for eliminati...Continue Reading

References

Jun 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·J M McCord
Mar 11, 2000·Neuroscience Research·V ErakovićA Simonić
Apr 13, 2000·The European Journal of Neuroscience·M V FrantsevaP L Carlen
Apr 27, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Letícia V Costa-LotufoGlauce S B Viana
Aug 2, 2003·Arquivos de neuro-psiquiatria·Rivelilson Mendes de FreitasMarta Maria de França Fonteles
Jan 1, 1954·Methods of Biochemical Analysis·A C MAEHLY, B CHANCE

❮ Previous
Next ❯

Citations

May 26, 2005·Brain Research·Simone Denise SalamoniRicardo Vaz Breda
Jun 26, 2007·Neurological Research·Kranthi Kumari NagaPhanithi Prakash Babu
Dec 15, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jaroslava FolbergrováJosef Houštěk
Dec 23, 2009·Pharmacology, Biochemistry, and Behavior·Itala Mônica de Sales SantosJoaquín Jordán
Oct 14, 2009·Neurochemistry International·Danielle Silveira MacêdoFrancisca Cléa Florenço de Sousa
Oct 24, 2009·Epilepsy Research·Simon Waldbaum, Manisha Patel
Feb 13, 2007·Clinical Biochemistry·Jeffrey LópezJosé Y Bauzá
May 2, 2006·Brain Research Bulletin·S TejadaS Esteban
Aug 9, 2005·Neuroscience Letters·Danielle Silveira MacêdoFrancisca Cléa Florenço de Sousa
Dec 2, 2008·Expert Opinion on Pharmacotherapy·P Uma DeviDivya Vohora
Jul 6, 2010·Arquivos de neuro-psiquiatria·Itala Mônica de Sales SantosRivelilson Mendes de Freitas
Jul 6, 2010·Arquivos de neuro-psiquiatria·Adriana da Rocha ToméRivelilson Mendes de Freitas
Feb 20, 2018·BioMed Research International·Jintanaporn WattanathornSomsak Tiamkao
Nov 24, 2005·Epilepsia·Annamaria Vezzani, Tiziana Granata
Dec 18, 2013·Physiological Research·J Folbergrová
Aug 24, 2005·Pharmacology, Biochemistry, and Behavior·Viviane S NascimentoMarta M F Fonteles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.