Catalase-independent early-gene expression in rat brain following acute ethanol exposure

Brain Research
Juan J Canales

Abstract

Early-gene expression evoked by acute ethanol treatment was studied in rat brain by quantitative immunocytochemistry, with reference to ethanol metabolism by the enzyme catalase. Colocalization with mu-opioid receptor (MOR) sites was also examined. Ethanol challenges [1, 2.5, and 4 g/kg intraperitoneally (i.p.)] evoked dose-dependent increases in c-Fos expression in several brain regions, but overlap with MOR-rich sites was only partial. Strong inhibition of brain catalase activity (ca. 60%) with 3-amino-1,2,4-triazole (AT, 1 g/kg i.p.) did not alter ethanol-induced c-Fos nor Krox-24 expression in any of the brain regions analyzed. This evidence demonstrates that catalase-mediated metabolism is not a requisite for c-Fos nor Krox-24 induction in rat brain following acute ethanol treatment, and suggests that ethanol is by itself capable of eliciting strong neuronal and circuit-level adaptations in the nervous system.

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Citations

Nov 15, 2011·Neurotoxicology and Teratology·Kristina E PeritBruce E McKay
Mar 24, 2009·Alcoholism, Clinical and Experimental Research·Catherine VilpouxMickael Naassila
Aug 2, 2012·Developmental Psychobiology·Elena I VarlinskayaLinda P Spear
Oct 7, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Rodriguez-AlarcónA Salvador
Jun 13, 2006·Brain Research Reviews·Andrey E Ryabinin, Adam Z Weitemier
Aug 2, 2014·Brain Structure & Function·T A RetsonE J Van Bockstaele
Aug 10, 2011·Neuroscience and Biobehavioral Reviews·Mercè CorreaElio Acquas

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