Nov 19, 2019

Catalpol and Mannitol, Two Components of Rehmannia glutinosa , Exhibit Anticonvulsant Effects Probably via GABAA Receptor Regulation

Biomolecules & Therapeutics
Mikyung KimHee Jin Kim


Epilepsy is a brain disorder that affects millions of people worldwide and is usually managed using currently available antiepileptic drugs, which result in adverse effects and are ineffective in approximately 20-25% of patients. Thus, there is growing interest in the development of new antiepileptic drugs with fewer side effects. In a previous study, we showed that a Rehmannia glutinosa (RG) water extract has protective effects against electroshock- and pentylenetetrazol (PTZ)-induced seizures, with fewer side effects. In this study, the objective was to identify the RG components that are responsible for its anticonvulsant effects. Initially, a number of RG components (aucubin, acteoside, catalpol, and mannitol) were screened, and the anticonvulsant effects of different doses of catalpol, mannitol, and their combination on electroshock- and chemically (PTZ or strychnine)-induced seizures in mice, were further assessed. Gamma-aminobutyric acid (GABA) receptor binding assay and electroencephalography (EEG) analysis were conducted to identify the potential underlying drug mechanism. Additionally, treated mice were tested using open-field and rotarod tests. Catalpol, mannitol, and their combination increased threshold against ele...Continue Reading

  • References27
  • Citations1


  • References27
  • Citations1


Mentioned in this Paper

Brain Diseases
Laboratory Procedures
Regulation of Biological Process
Stimulators, Electrical, Brain, Convulsive Therapy
GABA Antagonists

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