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Catalysis by acetylcholinesterase: evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis

Proceedings of the National Academy of Sciences of the United States of America

Oct 1, 1975

T L Rosenberry

PMID: 668

Abstract

Inferences about the catalytic mechanism of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) are frequently made on the basis of a presumed analogy with chymotrypsin, EC 3.4.21.1. Although both enzymes are serine hydrolases, several differences in the steady-state kinetic prop...read more

Mentioned in this Paper

ACHE Gene
Hydrogen-Ion Concentration
Hydrolase
Acetylcholinesterase Measurement
Metabolic Inhibition
Phenylacetate
Mathematics
Plasma Protein Binding Capacity
Serine
Structure-Activity Relationship
Paper Details
References
  • References18
  • Citations41
12
  • References18
  • Citations41
12345

Catalysis by acetylcholinesterase: evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis

Proceedings of the National Academy of Sciences of the United States of America

Oct 1, 1975

T L Rosenberry

PMID: 668

DOI:

Abstract

Inferences about the catalytic mechanism of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) are frequently made on the basis of a presumed analogy with chymotrypsin, EC 3.4.21.1. Although both enzymes are serine hydrolases, several differences in the steady-state kinetic prop...read more

Mentioned in this Paper

ACHE Gene
Hydrogen-Ion Concentration
Hydrolase
Acetylcholinesterase Measurement
Metabolic Inhibition
Phenylacetate
Mathematics
Plasma Protein Binding Capacity
Serine
Structure-Activity Relationship

Related Papers

Paper Details
References
  • References18
  • Citations41
12
  • References18
  • Citations41
12345
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