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Catalysis by acetylcholinesterase: evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis

Proceedings of the National Academy of Sciences of the United States of America

Oct 1, 1975

Terrone L Rosenberry

PMID: 668

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Abstract

Inferences about the catalytic mechanism of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) are frequently made on the basis of a presumed analogy with chymotrypsin, EC 3.4.21.1. Although both enzymes are serine hydrolases, several differences in the steady-state kinetic prop...read more

Mentioned in this Paper

Enzymes, antithrombotic
Enzymes, peripheral vasodilators
Acetylcholine Measurement
Cathepsin G
Mathematics
Acetylcholine Sulfate (1: 1)
Hydrolase
Enzymes, hematological
Metabolic Inhibition
Structure-Activity Relationship
Paper Details
References
    • References18
    • Citations38
    • References18
    • Citations38
  • Catalysis by acetylcholinesterase: evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis

    Proceedings of the National Academy of Sciences of the United States of America

    Oct 1, 1975

    Terrone L Rosenberry

    PMID: 668

    DOI:

    Abstract

    Inferences about the catalytic mechanism of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) are frequently made on the basis of a presumed analogy with chymotrypsin, EC 3.4.21.1. Although both enzymes are serine hydrolases, several differences in the steady-state kinetic prop...read more

    Mentioned in this Paper

    Enzymes, antithrombotic
    Enzymes, peripheral vasodilators
    Acetylcholine Measurement
    Cathepsin G
    Mathematics

    Related Papers

    Paper Details
    References
    • References18
    • Citations38
    • References18
    • Citations38
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