Catalytic Aerobic Dehydrogenation of Nitrogen Heterocycles Using Heterogeneous Cobalt Oxide Supported on Nitrogen-Doped Carbon

Organic Letters
Andrei V Iosub, Shannon S Stahl

Abstract

Dehydrogenation of (partially) saturated heterocycles provides an important route to heteroaromatic compounds. A heterogeneous cobalt oxide catalyst, previously employed for aerobic oxidation of alcohols and amines, is shown to be effective for aerobic dehydrogenation of various 1,2,3,4-tetrahydroquinolines to the corresponding quinolines. The reactions proceed in good yields under mild conditions. Other N-heterocycles are also successfully oxidized to their aromatic counterparts.

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Citations

Jun 21, 2016·Journal of the American Chemical Society·Feng ChenMatthias Beller
Oct 5, 2016·The Journal of Organic Chemistry·Feng PengYingju Xu
Aug 20, 2016·Angewandte Chemie·Masahiro Kojima, Motomu Kanai
Aug 15, 2017·Chemistry : a European Journal·Manoj K SahooEkambaram Balaraman
Mar 12, 2016·Organic & Biomolecular Chemistry·Kishore NatteMatthias Beller
Dec 17, 2017·Nature Communications·Garima JaiswalEkambaram Balaraman

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