Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements.

Chemical Communications : Chem Comm
Wande ZhangBaomin Wang

Abstract

An organocatalytic asymmetric process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and an axially chiral styrene unit were obtained in high yield with excellent diastereoselectivity and enantioselectivity (up to 99% ee, >20 : 1 dr). The process has the characteristics of mild reaction conditions, simple operation and broad substrate scope. The result of gram-scale reaction indicates that the reaction has good practicability.

References

May 14, 2004·Journal of Medicinal Chemistry·Michael P ClarkMichael J Janusz
Apr 26, 2005·Bioorganic & Medicinal Chemistry·Maria Grazia FerlinGiovanni Biggio
Jan 4, 2008·BMC Neuroscience·Aurelie VandenbeuchSue C Kinnamon
Aug 3, 2011·Chemical Reviews·Santos FusteroAntonio Simón-Fuentes
Jun 24, 2015·Accounts of Chemical Research·Yao WangPeng-Fei Xu
Jul 17, 2015·Chemical Communications : Chem Comm·Pankaj ChauhanDieter Enders
Dec 18, 2015·Angewandte Chemie·Daniel HackDieter Enders
Oct 7, 2016·Chemical Communications : Chem Comm·Xiaoze BaoBaomin Wang
Apr 7, 2017·Journal of the American Chemical Society·Simon Krautwald, Erick M Carreira
May 22, 2018·Journal of the American Chemical Society·Shiqi JiaHailong Yan
Aug 14, 2018·Journal of the American Chemical Society·José A CarmonaJosé M Lassaletta
Aug 18, 2018·Organic & Biomolecular Chemistry·Kai YangBaomin Wang
Sep 19, 2018·Chemical Communications : Chem Comm·Siyuan LiuBaomin Wang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Agents and Actions. Supplements
H Schadewaldt
Allergologia et immunopathologia
M RubioE Ordoqui
© 2021 Meta ULC. All rights reserved