Catalytic asymmetric synthesis of enantioenriched heterocycles bearing a C-CF3 stereogenic center

Chemistry : a European Journal
Yi-Yong HuangNorio Shibata

Abstract

Given the important agricultural and medicinal application of optically pure heterocycles bearing a trifluoromethyl group at the stereogenic carbon center in the heterocyclic framework, the exploration of efficient and practical synthetic strategies to such types of molecules remains highly desirable. Catalytic enantioselective synthesis has one clear advantage that it is more cost-effective than other synthetic methods, but remains limited by challenges in achieving excellent yield and stereoselectivities with a low catalyst loading. Thus far, numerous models of organo- and organometal-catalyzed asymmetric reactions have been exploited to achieve this elusive goal over the past decade. This review article describes recent progress on this research topic, and focuses on an understanding of the catalytic asymmetric protocols exemplified in the catalytic enantioselective synthesis of a wide range of complex enantioenriched trifluoromethylated heterocycles.

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Citations

Jul 17, 2015·Organic Letters·Satoshi OkusuNorio Shibata
Aug 1, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Sadayuki ArimoriNorio Shibata
May 20, 2017·Organic & Biomolecular Chemistry·Yuanyuan ZhuRui Wang
Nov 13, 2020·Beilstein Journal of Organic Chemistry·Ziyi LiJianlin Han
May 27, 2020·ACS Omega·Munenori InoueNorio Shibata
Sep 13, 2017·The Journal of Organic Chemistry·Jiandong WangNorio Shibata
Jun 17, 2020·Journal of the American Chemical Society·Liang FuGuosheng Liu

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