Catalytic Asymmetric Total Synthesis of (-)-Actinophyllic Acid

Journal of the American Chemical Society
Lingchao CaiOhyun Kwon

Abstract

Described herein is a catalytic asymmetric total synthesis of (-)-actinophyllic acid, with the key step being a chiral phosphine-catalyzed [3 + 2] annulation between an imine and an allenoate to form a pyrroline intermediate in 99% yield and 94% ee. The synthesis also features CuI-catalyzed coupling between a ketoester and a 2-iodoindole to shape the tetrahydroazocine ring; intramolecular alkylative lactonization; SmI2-mediated intramolecular pinacol coupling between ketone and lactone subunits to assemble the complex skeleton of (-)-actinophyllic acid; and an unprecedented regioselective dehydroxylation.

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Oct 7, 2016·Accounts of Chemical Research·Erik Stempel, Tanja Gaich
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Sep 12, 2018·Chemical Reviews·Huanzhen NiYixin Lu
Sep 28, 2018·Chemical Reviews·Hongchao GuoOhyun Kwon

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