Catalytic Asymmetric Transfer Hydrogenation of trans -Chalcone Derivatives Using BINOL-derived Boro-phosphates

Organic Letters
Fei NaJon C Antilla

Abstract

Chiral phosphoric-acid-catalyzed asymmetric reductions of trans-chalcones have been investigated in this work. A BINOL-derived boro-phosphate-catalyzed asymmetric transfer hydrogenation of the carbon-carbon double bond of trans-chalcone derivatives employing borane as a hydride source was realized. This methodology provides a convenient procedure to access chiral dihydrochalone derivatives in high yields and with high enantioselectivities under mild conditions.

References

Jul 18, 2002·Chemical Communications : Chem Comm·Martin AlbrechtEduardo Peris
Mar 1, 2006·Chemical Society Reviews·Serafino Gladiali, Elisabetta Alberico
May 25, 2006·Angewandte Chemie·Sonja Mayer, Benjamin List
Sep 28, 2006·Journal of the American Chemical Society·Jamison B TuttleDavid W C MacMillan
Oct 13, 2006·Journal of the American Chemical Society·Nolwenn J A Martin, Benjamin List
May 12, 2007·Angewandte Chemie·Magnus Rueping, Andrey P Antonchick
Oct 27, 2007·Accounts of Chemical Research·Takao Ikariya, A John Blacker
Nov 7, 2007·Chemical Reviews·Takahiko Akiyama
Jul 31, 2008·Chemistry : a European Journal·Sheng-Mei Lu, Carsten Bolm
Aug 30, 2011·Journal of the American Chemical Society·Taichiro TougeTakao Ikariya
Sep 29, 2011·Angewandte Chemie·Zuhui ZhangJon C Antilla
Jan 28, 2012·Chemical Society Reviews·Chao Zheng, Shu-Li You
Mar 20, 2014·Chemical Communications : Chem Comm·Dieter EndersAndreas Rembiak
Dec 9, 2014·Journal of the American Chemical Society·Zhaobin WangJianwei Sun
Jun 11, 2015·Chemical Reviews·Dong Wang, Didier Astruc
Feb 24, 2017·Organic & Biomolecular Chemistry·Ana Maria Faísca Phillips, Armando J L Pombeiro
Mar 31, 2018·Science·Nobuya TsujiBenjamin List
Dec 15, 2018·Chemical Reviews·Duo Wei, Christophe Darcel
Feb 16, 2019·Journal of the American Chemical Society·Jie OuyangBenjamin List

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of the New York Academy of Sciences
William S KnowlesB D Vineyard
Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]
Francisco Foubelo, Miguel Yus
© 2021 Meta ULC. All rights reserved