'Catalytic' doses of fructose may benefit glycaemic control without harming cardiometabolic risk factors: a small meta-analysis of randomised controlled feeding trials.

The British Journal of Nutrition
John L SievenpiperDavid J A Jenkins

Abstract

Contrary to concerns that fructose may have adverse metabolic effects, there is evidence that small, 'catalytic' doses ( ≤ 10 g/meal) of fructose decrease the glycaemic response to high-glycaemic index meals in human subjects. To assess the longer-term effects of 'catalytic' doses of fructose, we undertook a meta-analysis of controlled feeding trials. We searched MEDLINE, EMBASE, CINAHL and the Cochrane Library. Analyses included all controlled feeding trials ≥ 7 d featuring 'catalytic' fructose doses ( ≤ 36 g/d) in isoenergetic exchange for other carbohydrates. Data were pooled by the generic inverse variance method using random-effects models and expressed as mean differences (MD) with 95 % CI. Heterogeneity was assessed by the Q statistic and quantified by I 2. The Heyland Methodological Quality Score assessed study quality. A total of six feeding trials (n 118) met the eligibility criteria. 'Catalytic' doses of fructose significantly reduced HbA1c (MD - 0·40, 95 % CI - 0·72, - 0·08) and fasting glucose (MD - 0·25, 95 % CI - 0·44, - 0·07). This benefit was seen in the absence of adverse effects on fasting insulin, body weight, TAG or uric acid. Subgroup and sensitivity analyses showed evidence of effect modific...Continue Reading

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Citations

Feb 14, 2013·European Journal of Clinical Nutrition·T M S Wolever
Dec 29, 2013·Current Opinion in Lipidology·John L SievenpiperArash Mirrahimi
Mar 16, 2013·Advances in Nutrition·David M Klurfeld
Sep 6, 2014·Journal of Nutritional Science·Amin EsfahaniCyril W C Kendall
Jun 25, 2013·Current Hypertension Reports·Vanessa HaJohn L Sievenpiper
May 16, 2014·Canadian Journal of Diabetes·Paula D DworatzekSandra L Williams
Jul 5, 2015·Mayo Clinic Proceedings·John L SievenpiperFred Brouns
Jul 23, 2015·Journal of Nutrition and Metabolism·Astrid Kolderup, Birger Svihus
Aug 22, 2014·Journal of the American College of Nutrition·Viranda H JayalathDavid J A Jenkins
Jun 9, 2016·Obesity·Maira Bes-RastrolloMiguel A Martinez-Gonzalez
Apr 2, 2014·Journal of Epidemiology and Community Health·Oyinlola OyebodeJennifer S Mindell
Aug 9, 2016·Canadian Journal of Diabetes·John L Sievenpiper
Dec 14, 2017·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·M ShafiqueN Guess
Sep 21, 2017·Nutrients·Bettina Geidl-Flueck, Philipp A Gerber
Oct 7, 2017·Nutrition and Metabolic Insights·Shirley F EvansEdralin A Lucas
Sep 12, 2015·Journal of the American Heart Association·Laura ChiavaroliJohn L Sievenpiper
Oct 24, 2018·The Proceedings of the Nutrition Society·Javier T Gonzalez, James A Betts
Dec 4, 2012·Journal of the American College of Nutrition·John L Sievenpiper, UNKNOWN Toronto 3D (Diet, Digestive Tract, and Disease) Knowledge Synthesis and Clinical Trials Unit
Apr 25, 2018·European Journal of Clinical Nutrition·Theodora Gourdomichali, Emilia Papakonstantinou
Dec 12, 2018·Nutrition & Diabetes·Effie ViguilioukCyril W C Kendall
Nov 8, 2018·Current Developments in Nutrition·David J TyborMei Chung
Oct 8, 2020·Antioxidants·Alessandra BarbieraBianca Maria Scicchitano
May 1, 2016·Comprehensive Reviews in Food Science and Food Safety·Roger A ClemensSvetlana Zivanovic
Mar 30, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Catherine R BraunsteinJohn L Sievenpiper

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NCT01363791

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