Catalytic enantioselective aldol reactions

Chemical Society Reviews
Yasuhiro YamashitaShū Kobayashi

Abstract

Recent developments in catalytic asymmetric aldol reactions have been summarized. Enantioselective aldol reactions are important methods to synthesize β-hydroxy carbonyl compounds in optical pure form, and as such, numerous successful chiral catalysts were designed and applied for asymmetric aldol reactions. This review article is organized under the categories of: (1) catalytic enantioselective aldol reactions of preformed enolates, (2) catalytic enantioselective direct-type aldol reactions using chiral metal catalysts, (3) catalytic enantioselective direct-type aldol reactions using organocatalysts, (4) catalytic enantioselective aldol reactions in aqueous media. Examples of the aldol reactions that employ simple carbonyl compounds will be also the focus of this review.

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Citations

Jul 3, 2018·Organic & Biomolecular Chemistry·Neng-Jun ZhongLi Liu
Jan 18, 2019·Angewandte Chemie·Roman PlutaMasakatsu Shibasaki
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Methods Mentioned

BETA
NMR
X-ray
acetylation
PCR

Software Mentioned

DYKAT
FSA
ClickFerrophos

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