Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols

Journal of Agricultural and Food Chemistry
Jeong-Youn JoMary Ann Lila

Abstract

Previously, we isolated mixed polyphenolic fractions on a toyopearl matrix (TP-2 to TP-6) from grape cell cultures that were highly potent catalytic inhibitors in a human DNA topoisomerase II assay for cancer chemoprevention. The objectives of this study were to evaluate the potency of, and potential interactions between, individual fractions and some of the purified bioactive polyphenols that comprise these fractions on human DNA topoisomerase II catalytic activity. Treatments that combined anthocyanin-rich fractions (TP-2; 0.5 or 2.0 microg of dried material/mL), fractions containing catechins, procyanidin dimers, and flavanones (TP-4; 0.25 microg of dried material/mL), and/or fractions enriched with procyanidin oligomers and polymers (TP-6; 0.15 or 0.5 microg of dried material/mL) showed additive effects toward catalytic inhibition of the enzyme. Epicatechin gallate (IC50 = 0.029 microM), myricetin (0.39 microM), procyanidin B2 (PB2, 4.5 microM), and resveratrol (65.7 microM), constituents of the most bioactive mixed fraction from grape cell culture (TP-4), each individually provided potent catalytic inhibition of topoisomerase II. In addition, potentiating interactions between the PB2 and the other polyphenolic constituents...Continue Reading

References

Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Michelle MouriaStephen J Pandol
Jul 31, 2003·Pharmacology & Therapeutics·Annette K LarsenAndrzej Skladanowski
Aug 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ronald D Snyder, Peter J Gillies
Sep 27, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F Bianchini, H Vainio
Nov 5, 2003·Brain Research Bulletin·Angela ConteDavide Tagliazucchi
Mar 5, 2004·Journal of Agricultural and Food Chemistry·Gad G YousefMary Ann Lila
Jan 15, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H BabichH L Zuckerbraun
Mar 17, 2005·Journal of Agricultural and Food Chemistry·Elvira Gonzalez de MejiaHideka Kobayashi

❮ Previous
Next ❯

Citations

May 13, 2009·Antioxidants & Redox Signaling·Shazib Pervaiz, Andrea Lisa Holme
Apr 7, 2011·Biological & Pharmaceutical Bulletin·Eisaku YamamotoKeiji Hasumi
May 17, 2011·Pharmacology & Therapeutics·Beatrice MercorelliArianna Loregian
Jan 14, 2009·Phytotherapy Research : PTR·Marjan Nassiri-Asl, Hossein Hosseinzadeh
Feb 1, 2011·Molecular Nutrition & Food Research·Melanie EsselenDoris Marko
Dec 29, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Hilal ZaidBashar Saad
Jun 24, 2015·Annals of the New York Academy of Sciences·Robert G BrittonKaren Brown
May 9, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Benjamin DemoulinPatrick Dumont
May 19, 2004·Toxicology·Antonio E AlegriaOsvaldo Cox
Nov 7, 2015·Archives of Toxicology·Isabel Anna Maria GrohMelanie Esselen
Oct 28, 2017·The Journal of Biological Chemistry·Joyce H LeeJames M Berger
Dec 18, 2007·Molecular Nutrition & Food Research·Patricia M Aron, James A Kennedy
Jan 15, 2021·Chemistry : a European Journal·Daniela Mélanie Delannoy LópezStéphane Quideau
Feb 3, 2009·Chemical Research in Toxicology·Melanie EsselenDoris Marko
Sep 10, 2008·Journal of Agricultural and Food Chemistry·Jessica FritzDoris Marko
Dec 27, 2013·Journal of Agricultural and Food Chemistry·Simone A BaechlerDoris Marko
Jun 27, 2007·Bioorganic & Medicinal Chemistry Letters·Xinming LiTianhu Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Jeong-Youn JoMary Ann Lila
Nature Reviews. Drug Discovery
Joseph A Baur, David A Sinclair
The Journal of Infectious Diseases
Anna T PalamaraEnrico Garaci
© 2021 Meta ULC. All rights reserved