PMID: 22343977DOI: 10.1039/c2cc17377hFeb 22, 2012Paper
Catalytic metallodrugs targeting HCV IRES RNA
Chemical Communications : Chem Comm
Seth Bradford, J A Cowan
Abstract
A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with K(M) of 0.85 μM, k(cat) of 0.53 min(-1), and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC(50)) of 0.58 μM in an HCV cellular replicon assay.
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Feb 6, 2013·Chemical Communications : Chem Comm·Jeff C JoynerJ A Cowan
Sep 4, 2012·Nucleic Acids Research·Jeff C JoynerJ A Cowan
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