Catalytic metallodrugs targeting HCV IRES RNA

Chemical Communications : Chem Comm
Seth Bradford, J A Cowan

Abstract

A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with K(M) of 0.85 μM, k(cat) of 0.53 min(-1), and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC(50)) of 0.58 μM in an HCV cellular replicon assay.

References

Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D M WilliamsF Eckstein
Jun 1, 1968·Canadian Journal of Biochemistry·B Sarkar, Y Wigfield
Mar 1, 1981·International Journal of Peptide and Protein Research·P C MontecucchiV Erspamer
Apr 26, 1995·Biochemical and Biophysical Research Communications·C Harford, B Sarkar
Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Feb 28, 2001·FEBS Letters·J GroganF G Oppenheim
Jan 13, 2006·Journal of the American Chemical Society·Yan Jin, J A Cowan
Jul 29, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Nikhil H Gokhale, J A Cowan
Mar 16, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yan Jin, J A Cowan
Aug 18, 2009·Chemistry : a European Journal·Lalintip Hocharoen, James A Cowan
Sep 19, 2009·Current Opinion in Pharmacology·Tetsuro ShimakamiStanley M Lemon
Apr 9, 2010·The New England Journal of Medicine·John G McHutchisonUNKNOWN PROVE3 Study Team

❮ Previous
Next ❯

Citations

Feb 6, 2013·Chemical Communications : Chem Comm·Jeff C JoynerJ A Cowan
Sep 4, 2012·Nucleic Acids Research·Jeff C JoynerJ A Cowan
Mar 15, 2015·Current Opinion in Chemical Biology·Joan J Soldevila-Barreda, Peter J Sadler
Jun 17, 2016·Wiley Interdisciplinary Reviews. RNA·Thomas Hermann
Jul 6, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J C Joyner, J A Cowan
Jul 9, 2017·Chemistry : a European Journal·Zhen Yu, James A Cowan
Nov 20, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Martin James RossJ A Cowan
Jan 27, 2019·Chemistry : a European Journal·Silvia Alonso-de CastroLuca Salassa
Mar 21, 2015·Nature Communications·Joan J Soldevila-BarredaPeter J Sadler
Sep 14, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Insiya FidaiJ A Cowan
May 23, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Gianni SavaAlberta Bergamo
May 3, 2013·Chemical Communications : Chem Comm·Nicolas P E Barry, Peter J Sadler
Mar 13, 2014·Angewandte Chemie·Zhe LiuPeter J Sadler
Feb 2, 2021·Chemical Reviews·Jasmin PortelinhaAlfredo M Angeles-Boza
Nov 5, 2016·Journal of Inorganic Biochemistry·Elena AlbertiDaniela Donghi
Jan 8, 2018·Journal of Inorganic Biochemistry·Xiuxiu WangJing Zhao
Nov 21, 2017·Current Opinion in Chemical Biology·Zhen Yu, J A Cowan
Oct 22, 2013·Journal of Medicinal Chemistry·Sergey M DibrovThomas Hermann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Jeff C Joyner, J A Cowan
Nature Reviews. Gastroenterology & Hepatology
Sandra Ciesek, Michael P Manns
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Caitlin C BurkeDouglas T Dieterich
© 2022 Meta ULC. All rights reserved