Catalytic transfer hydrogenation of arenes and heteroarenes

Chemistry : a European Journal
Coralie GelisFrank Glorius

Abstract

Transfer hydrogenation reactions are of great interest in order to reduce diverse molecules under mild reaction conditions. To date, this type of reaction has only been successfully applied to alkenes, alkynes and polarized unsaturated compounds such as ketones, imines, pyridines etc. The reduction of benzene derivatives via transfer hydrogenation has never been described, which is likely due to the high energy barrier required to dearomatize these compounds. In this context, we have developed a catalytic transfer hydrogenation reaction for the reduction of benzene derivatives and heteroarenes to form complex 3-dimensional scaffolds bearing various functional groups at room temperature without needing compressed hydrogen gas.

References

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Jan 10, 2014·Chemistry : a European Journal·Xiaoshuang GaoGuohua Liu
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Oct 4, 2016·Journal of the American Chemical Society·Guixiang ZengShigeyoshi Sakaki
Nov 1, 2018·Chemistry : a European Journal·Thomas M MaierRobert Wolf
Nov 6, 2018·Angewandte Chemie·Marco WollenburgFrank Glorius
Mar 1, 2019·Journal of the American Chemical Society·Feng WangJosep Cornella
Apr 10, 2019·Chemistry : a European Journal·Devin H A BoomJ Chris Slootweg
Apr 10, 2020·Chemistry : a European Journal·Zackaria NairoukhFrank Glorius

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Citations

Apr 24, 2021·Journal of the American Chemical Society·Patrick D ParkerVy M Dong
Apr 9, 2021·Angewandte Chemie·Arne HeuslerFrank Glorius
Nov 23, 2021·Journal of the American Chemical Society·Haibo WuPher G Andersson

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