Abstract
The aim of this study was to study long-term visual outcome and cataract development in children and adolescents after hematopoietic stem cell transplantation (HSCT) in childhood. Best corrected visual acuity (BCVA), refraction and lens status were examined in a prospective study of 139 children and adolescents. In total, 139 patients (58 female), median age 6.6 years at HSCT (range 0.4-17.5 years), were followed up for a median of 8.0 years (1-19.4 years). Median BCVA in the better eye was 1.0 decimal. Altogether 19 of 131 patients developed cataract requiring surgery, while 46 developed less prominent lens opacities and 66 had clear lenses at time of latest follow-up. Patients conditioned with total body irradiation had a higher risk of developing lens opacities or cataract (p < 0.0001) as did patients with malignant disease, irrespective of irradiation treatment (p < 0.0001). Cumulative analysis showed that 50% of all patients had developed lens opacities/cataract after 10.2 years. Patients who ultimately needed cataract surgery developed cataract earlier than others (p = 0.006). Lens opacities or cataract were more common in children or adolescents with malignant disease and after conditioning with irradiation. Regular opht...Continue Reading
References
Sep 1, 1986·Survey of Ophthalmology·R C Urban, E Cotlier
Oct 1, 1993·Archives of Ophthalmology·J P DunnG Santos
Jan 1, 1993·The British Journal of Ophthalmology·B M Calissendorff, P Bolme
Jan 26, 1999·Ophthalmology·J S NgM O Tso
Jul 13, 1999·Strabismus·A RydbergE Lindstedt
Aug 12, 1999·Ophthalmology·D W SuhJ D Kivlin
Apr 16, 2002·Acta Ophthalmologica Scandinavica·Gerd HolmströmBerit Calissendorff
Sep 30, 2004·Acta Ophthalmologica Scandinavica·Konstantin MoutakisJanet Hall-Lindberg
May 29, 2007·Bone Marrow Transplantation·C FerryG Socié
Aug 21, 2007·Bone Marrow Transplantation·G MichelP Auquier
Aug 30, 2007·Acta Ophthalmologica Scandinavica·Kristina Teär FahnehjelmJacek Winiarski
Dec 21, 2007·Acta Ophthalmologica·Kristina Teär FahnehjelmJacek Winiarski
Oct 22, 2008·Bone Marrow Transplantation·C M LöfU Forinder
Sep 5, 2009·Ophthalmology·Khalid F TabbaraMahmoud Aljurf
May 22, 2010·Cornea·Arnaud C WestenengAniki Rothova
May 31, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mats RembergerOlle Ringdén
Aug 1, 2012·Pediatric Blood & Cancer·Jean M Mulcahy LevyArthur K Liu
Mar 2, 2013·JAMA Ophthalmology·Viera Kalinina AyusoJoke de Boer
Jan 29, 2014·Current Opinion in Hematology·Samantha M Jaglowski, Steven M Devine
Feb 25, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Michael KinoriRuth Huna-Baron
Sep 4, 2015·Acta Paediatrica·Kristina Teär FahnehjelmJacek Winiarski
Citations
Jun 6, 2019·Journal of Radiation Research·Yu ZhaoSaijun Fan
Sep 4, 2015·Acta Paediatrica·Kristina Teär FahnehjelmJacek Winiarski
Feb 9, 2018·Pediatric Transplantation·Kristina Teär FahnehjelmUlla Ek
Dec 12, 2018·Bone Marrow Transplantation·Yoshihiro InamotoNuria Valdés-Sanz
Apr 13, 2019·Pediatric Hematology and Oncology·Fernand FreyconBéatrice Trombert-Paviot
Dec 7, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yoshihiro InamotoNuria Valdés-Sanz