Cataract as Early Ocular Complication in Children and Adolescents with Type 1 Diabetes Mellitus

International Journal of Endocrinology
Marko ŠimunovićVeselin Škrabić

Abstract

Cataract is a rare manifestation of ocular complication at an early phase of T1DM in the pediatric population. The pathophysiological mechanism of early diabetic cataract has not been fully understood; however, there are many theories about the possible etiology including osmotic damage, polyol pathway, and oxidative stress. The prevalence of early diabetic cataract in the population varies between 0.7 and 3.4% of children and adolescents with T1DM. The occurrence of diabetic cataract in most pediatric patients is the first sign of T1DM or occurs within 6 months of diagnosis of T1DM. Today, there are many experimental therapies for the treatment of diabetic cataract, but cataract surgery continues to be a gold standard in the treatment of diabetic cataract. Since the cataract is the leading cause of visual impairment in patients with T1DM, diabetic cataract requires an initial screening as well as continuous surveillance as a measure of prevention and this should be included in the guidelines of pediatric diabetes societies.

References

Jan 1, 1988·Ophthalmic Research·C CostagliolaE Rinaldi
Nov 1, 1993·Clinical Pediatrics·M PhillipM W Preslan
Jan 1, 1996·Clinical Pediatrics·B Alouf, A G Pascual
Feb 1, 1997·Archives of Disease in Childhood·V DattaR F Harris
May 20, 1998·Journal of Paediatrics and Child Health·E L Montgomery, J A Batch
May 20, 1998·Acta Ophthalmologica Scandinavica·A Falck, L Laatikainen
Feb 26, 1999·Archives of Ophthalmology·M B Datiles, P F Kador
Apr 30, 2002·Journal of Cataract and Refractive Surgery·David A PlagerDaniel E Neely
Sep 26, 2006·Diabetes Research and Clinical Practice·Ciro CostagliolaFrancesco Parmeggiani
Feb 20, 2007·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·M Edward WilsonWilliam O Young
Jan 29, 2008·Current Drug Targets·Peter J Oates
Aug 21, 2008·Pediatric Diabetes·Chetanbabu M PatelFigen Ugrasbul
May 18, 2010·Diabetes/metabolism Research and Reviews·Irina G ObrosovaPeter F Kador
Jul 17, 2010·Journal of Ophthalmology·Andreas Pollreisz, Ursula Schmidt-Erfurth
Dec 17, 2010·Journal of Pediatric Ophthalmology and Strabismus·Veselin SkrabicDavor Galetovic
Jan 5, 2011·Ophthalmology·Wassia A KhajaKimberly G Yen
Feb 5, 2011·Pediatric Emergency Care·Neil G Uspal, Emily S Schapiro
Aug 2, 2011·Journal of Diabetes·Fumiko NagatomoAkihiko Ishihara
Sep 3, 2011·Clinical Ophthalmology·Kr HegdeSd Varma
May 15, 2012·Frontiers in Pharmacology·Wai Ho TangJohn Hwa
Aug 15, 2012·Current Opinion in Ophthalmology·Mary A O'Hara
Feb 5, 2013·BMJ Case Reports·Aruna GoturuIvor Lewis
Jan 1, 2012·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·M Edward Wilson, Rupal H Trivedi
Aug 21, 2013·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Mohammed Al Shamrani, Shahira Al Turkmani
Sep 26, 2013·Arquivos brasileiros de oftalmologia·Marcelo Carvalho VenturaWalton Nosé
Nov 22, 2013·Current Opinion in Ophthalmology·Shira L RobbinsDavid B Granet
Oct 18, 2014·Pediatric Diabetes·Jennifer J CouperUNKNOWN International Society for Pediatric and Adolescent Diabetes
Oct 18, 2014·Seminars in Ophthalmology·Mary C Whitman, Deborah K Vanderveen
Dec 30, 2014·Diabetes Care·UNKNOWN American Diabetes Association
Dec 30, 2014·Chemico-biological Interactions·Anson SnowJ Mark Petrash
Jan 23, 2015·Clinical Ophthalmology·Anagha Medsinge, Ken K Nischal
Feb 17, 2015·World Journal of Diabetes·Nihat SayinGökhan Pekel
Sep 6, 2015·Ophthalmology·Megan M GeloneckGil Binenbaum
Apr 5, 2016·Developments in Ophthalmology·Catherine GasperM Edward Wilson
May 4, 2016·Journal of Natural Products·Kun-Che ChangJ Mark Petrash
Sep 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chethan SampathMohamed Ahmedna
Oct 8, 2016·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Zachary P ElkinDouglas R Fredrick
Apr 26, 2017·Indian Journal of Ophthalmology·Sudarshan Kumar KhokharManish Mahabir
Apr 26, 2017·Endocrinología, Diabetes Y Nutrición·Emilio García García, Emilia García Robles

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Citations

Mar 21, 2019·World Journal of Diabetes·Hasan KiziltoprakYasin Sakir Goker
Feb 1, 2019·BMJ Case Reports·Jose Bernardo QuintosMelissa A Simon
Nov 3, 2020·International Journal of Endocrinology·Wen-Li LuLi-Min Chen
Apr 5, 2020·The Journal of Emergency Medicine·Elana CookMatthew D Thornton

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