Oct 13, 2016

Cataract induction by administration of nitroglycerin in cardiac patients through imbalance in redox status

Therapeutics and Clinical Risk Management
Rehab M El-GharabawyAmal H Al-Najjar


The objective of this study was to evaluate the role of nitroglycerin in the pathogenesis of cataract. Prospective study. This study was performed in adults from tertiary Saudi Arabian hospitals (34 males and 26 females in each group, aged from 40 to 60 years), who were divided into four groups with an equal number of subjects (control group, cardiac group, idiopathic cataract group, and a group of cardiac patients using nitroglycerin and with cataracts). Fasting glucose concentrations, blood glycated hemoglobin levels, lipid profiles, and levels of nitrite, conjugated dienes (CD), thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and reduced glutathione (GSH) were determined. Treatment of cardiac patients with nitroglycerin produced an imbalance in their systemic redox status, leading to the development of cataracts, which was reflected by a significant increase in the levels of nitrite, CD, and TBARS and a significant decrease in SOD activity and GSH, compared with idiopathic cataract patients. The results of correlation studies and multiple regression analysis revealed a significant positive correlation between different biochemical parameters (GSH, SOD, TBARS, CD, and nitrite) in the blood and len...Continue Reading

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Mentioned in this Paper

Thiobarbituric Acid Reactive Substances
Cardiac Patient
Pathogenic Aspects
Hemoglobin, Glycosylated
Research Subject

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