Catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Olivier RozenbaumB Bodaghi

Abstract

To report a case of severe acute retinal necrosis syndrome (ARN) associated with initial features of orbital cellulitis. A 49-year-old immunocompetent woman presented with unilateral painful orbital inflammation associated with deep visual loss due to ARN. Polymerase chain reaction (PCR) for detection of viral DNA was applied to ocular fluids. Immunohistochemistry for detection of viral antigens and histopathologic studies were performed on orbital biopsy specimens. HSV-2 DNA was detected by PCR in ocular fluids. Orbital biopsy disclosed non-specific inflammation without viral replication. Orbital inflammation resolved rapidly after the initiation of antiviral drugs, whereas intraocular inflammation worsened. Final ophthalmic examination disclosed no light perception due to optic atrophy. ARN and cellulitis may be associated. Consequently, ARN should be investigated in all patients with orbital inflammation, in order to initiate immediately an appropriate antiviral strategy.

References

Oct 1, 1977·Archives of Ophthalmology·J N BloomH E Kaufman
Jan 1, 1994·Eye·S J Vardy, G E Rose
Dec 19, 2002·The British Journal of Ophthalmology·T H C TranB Bodaghi

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Citations

Nov 18, 2018·Ocular Immunology and Inflammation·L M HassmanA P Bessette
Mar 12, 2019·American Journal of Ophthalmology Case Reports·Swarup S SwaminathanThomas A Albini
Aug 19, 2007·Current Opinion in Ophthalmology
Dec 29, 2007·Current Opinion in Ophthalmology

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