Catch bonding in the forced dissociation of a polymer endpoint

Physical Review. E
Cyril Vrusch, Cornelis Storm

Abstract

Applying a force to certain supramolecular bonds may initially stabilize them, manifested by a lower dissociation rate. We show that this behavior, known as catch bonding and by now broadly reported in numerous biophysics bonds, is generically expected when either or both the trapping potential and the force applied to the bond possess some degree of nonlinearity. We enumerate possible scenarios and for each identify the possibility and, if applicable, the criterion for catch bonding to occur. The effect is robustly predicted by Kramers theory and Mean First Passage Time theory and confirmed in direct molecular dynamics simulation. Among the catch scenarios, one plays out essentially any time the force on the bond originates in a polymeric object, implying that some degree of catch bond behavior is to be expected in many settings relevant to polymer network mechanics or optical tweezer experiments.

References

May 9, 2003·Nature·Bryan T MarshallCheng Zhu
Jun 14, 2005·Biophysical Journal·Yuriy V PereverzevWendy E Thomas
Dec 5, 2006·Biophysical Journal·Jizhong Lou, Cheng Zhu
Jun 25, 2008·Annual Review of Biophysics·Wendy E ThomasEvgeni Sokurenko
Jul 24, 2008·Annual Review of Biomedical Engineering·Wendy Thomas
Dec 31, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·E M HuismanG T Barkema
Jul 1, 2009·The Journal of Cell Biology·Fang KongCheng Zhu
Dec 31, 2010·Biophysical Journal·Hsieh Chen, Alfredo Alexander-Katz
Feb 17, 2011·The Journal of Chemical Physics·Yohichi Suzuki, Olga K Dudko
Jan 1, 2009·Macromolecules·Michael HinczewskiRoland R Netz
Jul 22, 2011·The Journal of Biological Chemistry·Krishna K SarangapaniCheng Zhu
Jan 15, 2014·Biophysical Journal·Matteo EscudéEugene M Terentjev
Jul 29, 2016·Soft Matter·M DennisonF C MacKintosh

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Citations

Aug 17, 2021·Advanced Functional Materials·Alan Pasha TabatabaiMichael P Murrell

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