Catching the adaptor-WDFY1, a new player in the TLR-TRIF pathway

EMBO Reports
Ramya Nandakumar, Søren R Paludan

Abstract

The innate immune system detects microbes and abnormal self through pattern recognition receptors (PRRs), which detect molecules that are either specific for microbes (such as lipopolysaccharide), present in much higher concentrations during infection (such as double-stranded RNA), or present in aberrant locations (such as cytosolic DNA) [1]. The Toll-like receptors (TLRs) are the best-described set of PRRs. TLRs are membrane-bound receptors localized on the plasma membrane and in endosomes, the ligand-binding regions of which face the extracellular environment and the endosomal lumen, respectively [1]. In this issue of EMBO Reports, Hu and colleagues report that WD-repeat and FYVE-domain-containing protein 1 (WDFY1) recruits the signaling adaptor TRIF to TLR3 and TLR4, thereby potentiating signaling from these PRRs (Fig 1); [2].

References

Aug 30, 2001·Nature Immunology·T HorngR Medzhitov
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masahiro YamamotoShizuo Akira
Oct 1, 2003·The Journal of Experimental Medicine·Katherine A FitzgeraldDouglas T Golenbock
Nov 23, 2011·The Journal of Clinical Investigation·Vanessa Sancho-ShimizuJean-Laurent Casanova
Mar 5, 2015·EMBO Reports·Yun-Hong HuYu Liu

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Citations

Mar 31, 2016·Scientific Reports·Samikshan DuttaKaustubh Datta
Apr 25, 2019·The Journal of Experimental Medicine·Fei NingXiaoyu Hu

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