Catechin inhibiting the H1N1 influenza virus associated with the regulation of autophagy.

Journal of the Chinese Medical Association : JCMA
Cheng-Chieh ChangSheng-Teng Huang

Abstract

The influenza virus is a highly infectious disease, with a notably rapid transmission rate. Autophagy is triggered by viral infection and is a survival mechanism exerted to maintain cellular homeostasis. Catechin is a representative phenolic acid which exerts anti-inflammatory responses against influenza A virus infection. The aim of this study is to explore the anti-H1N1 influenza virus effects by catechin associated with the restoration of autophagy. XTT assay was used to detect cellular viability. The inhibitory effects on the H1N1 influenza virus were assessed by hemagglutination assay, neuraminidase activity, and quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The protein levels of H1N1 influenza virulence and autophagic markers were detected by Western blot. We herein demonstrated that catechin had no cytotoxic effect on both infected and noninfected A549 cells and exerted protective effects on infected A549 cells. The results of the hemagglutination assay, neuraminidase activity, and qRT-PCR to examine viral load demonstrated that catechin effectively inhibited the replication of the H1N1 influenza virus. The virulent M2 protein and viral nucleoprotein were also inhibited after treatment with cate...Continue Reading

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Citations

Apr 9, 2021·The American Journal of Chinese Medicine·Jun-Yuan ZhangLian-Wen Qi
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad Amin Khazeei TabariRoja Rahimi
Jul 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li DengXiaoyin Chen

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Methods Mentioned

BETA
Assay
electrophoresis
FACS
PCR
flow cytometry

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Statistical Product and Service Solutions ( SPSS )
Quantity One
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