Catechin supplemented in a FOS diet induces weight loss by altering cecal microbiota and gene expression of colonic epithelial cells

Food & Function
Jianming LuoXichun Peng

Abstract

Our previous study showed that catechin controlled rats' body weights and changed gut microbiota composition when supplemented into a high-fructo-oligosaccharide (FOS) diet. This experiment is devised to further confirm the relationship between specific bacteria in the colon and body weight gain, and to investigate how specific bacteria impact body weight by changing the expression of colonic epithelial cells. Forty obese rats were divided into four groups: three catechin-supplemented groups with a high-FOS diet (100, 400, and 700 mg kg-1 d-1 catechin, orally administered) and one group with a high-FOS diet only. Food consumption and body weights were recorded each week. After one month of treatment, rats' cecal content and colonic epithelial cells were individually collected and analyzed with MiSeq and gene expression profiling techniques, respectively. Results identified some specific bacteria at the genus level-including the increased Parabacteroides sp., Prevotella sp., Robinsoniella sp., [Ruminococcus], Phascolarctobacterium sp. and an unknown genus of YS2, and the decreased Lachnospira sp., Oscillospira sp., Ruminococcus sp., an unknown genus of Peptococcaceae and an unknown genus of Clostridiales in rats' cecum-and eight...Continue Reading

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Citations

Mar 25, 2019·European Journal of Nutrition·Ratih Wirapuspita WisnuwardaniNathalie Michels
Jul 30, 2019·Journal of Food Biochemistry·Cheng ZhangXichun Peng
Oct 3, 2018·Phytotherapy Research : PTR·Alexandre Kleber SilveiraJosé Cláudio Fonseca Moreira
Dec 13, 2019·Journal of Agricultural and Food Chemistry·Jianhui LiuZhen-Yu Chen
Feb 12, 2021·Journal of Agricultural and Food Chemistry·Yina HuangHua Wei
Jan 9, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jinxin LiuLi Wang

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Methods Mentioned

BETA
scraping
PCR
RNA-seq

Software Mentioned

Goatools
R
bowtie
SPSS
bowtie2
EdgeR ( Empirical Analysis of Expression in

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