Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.

Biological Psychiatry
John M HettemaXiangning Chen

Abstract

Catechol-O-methyltransferase (COMT) has been investigated for its possible role in a wide range of psychiatric phenotypes. In particular, several studies support association of this gene with panic disorder and other anxiety-related traits. We examined the COMT gene for association with genetic risk across a range of anxiety spectrum phenotypes. We used multivariate structural equation modeling to select twin pairs scoring at the extremes of a latent genetic risk factor shared by neuroticism, several anxiety disorders, and major depression from a large population-based twin sample. With one member from each of these pairs, the resulting sample of 589 cases and 539 control subjects were entered into a two-stage association study in which genetic markers were screened in stage 1, the positive results of which were tested for replication in stage 2. The functional val158met polymorphism (rs4680) plus nine other single nucleotide polymorphism markers selected to capture the major allelic variation across the COMT locus were analyzed for differences between cases and control subjects. Although the val (G) allele of rs4680 showed marginally significant association in our combined stage 1 plus stage 2 sample, a high-risk haplotype of ...Continue Reading

References

Jul 1, 1975·Journal of Personality and Social Psychology·L Eaves, H Eysenck
Jan 1, 1990·Free Radical Biology & Medicine·J G Liehr, D Roy
Jun 1, 1985·Archives of General Psychiatry·D StanglC Corenthal
Jan 1, 1984·Genetic Epidemiology·R JardineA S Henderson
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A GogosM Karayiorgou
Jan 19, 1999·Archives of General Psychiatry·K S Kendler, C A Prescott
Mar 20, 1999·Genetic Analysis : Biomolecular Engineering·K J Livak
Feb 25, 2000·American Journal of Medical Genetics·A S HendersonS Easteal
Mar 10, 2000·Journal of Affective Disorders·J F ScherrerM T Tsuang
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Sep 9, 2000·Behavior Genetics·S Van GestelC Van Broeckhoven
Mar 20, 2001·Archives of General Psychiatry·K S KendlerM C Neale
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Apr 21, 2001·Biometrics·B Devlin, K Roeder
May 16, 2001·American Journal of Medical Genetics·P F SullivanR E Straub
Aug 16, 2001·The Journal of Nervous and Mental Disease·J M HettemaK S Kendler
Aug 22, 2001·Psychological Medicine·K S KendlerC A Prescott
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Mar 19, 2003·Lancet·Helen M ColhounGeorge Davey Smith
Jun 13, 2003·American Journal of Human Genetics·Nicholas J BrayMichael C O'Donovan
Jun 20, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Thalia C EleyIan Craig
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge
Oct 11, 2003·Trends in Genetics : TIG·Edwin J C G van den Oord, Patrick F Sullivan
Oct 24, 2003·American Journal of Human Genetics·Matthew Stephens, Peter Donnelly
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Mar 6, 2004·Molecular Endocrinology·Véronique BourdeauSylvie Mader
Mar 18, 2004·Journal of the National Cancer Institute·Sholom WacholderNathaniel Rothman
Mar 19, 2004·Genes and Immunity·C E LoweD G Clayton
Mar 31, 2004·Nature Genetics·Matthew L FreedmanDavid Altshuler
Jun 8, 2004·Bioinformatics·Jaime R Robles, Edwin J C G van den Oord
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Sep 1, 2004·The American Journal of Psychiatry·Monica McGrathImmaculata De Vivo
Mar 2, 2005·Molecular Psychiatry·E J C G van den Oord
Jun 11, 2005·Bioinformatics·Janis E Wigginton, Gonçalo R Abecasis

❮ Previous
Next ❯

Citations

Apr 11, 2009·Behavior Genetics·Gian Vittorio CapraraMaria Antonietta Stazi
Aug 10, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·K LehtoJ Harro
Nov 29, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Nathan A GillespieIan B Hickie
Jan 6, 2010·Molecular Psychiatry·E MaronJ Shlik
Apr 2, 2010·Schizophrenia Bulletin·Roman KotovEvelyn J Bromet
Dec 17, 2008·Genes, Brain, and Behavior·M-A EnochD Goldman
Jul 17, 2010·Genes, Brain, and Behavior·C M MiddeldorpD I Boomsma
Apr 2, 2009·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Yoon-Mi Hur
Oct 31, 2013·Journal of Cognitive Neuroscience·Janine BijsterboschSonia J Bishop
Jan 29, 2014·Brain Research·Kai MacDonald, David Feifel
Jan 28, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Martina KleinAlexandra Schosser
Dec 24, 2011·Behavioural Brain Research·Lieve DesbonnetColm M P O'Tuathaigh
Mar 8, 2011·Neurobiology of Learning and Memory·Marie-France MarinSonia J Lupien
Jun 19, 2010·Progress in Neurobiology·Esther M OpmeerAndré Aleman
Jan 20, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Murray B SteinJoel Gelernter
Feb 14, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jonas DonnerIiris Hovatta
Oct 14, 2011·Depression and Anxiety·John M HettemaPanos Fatouros
Mar 12, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Haroon I SheikhElizabeth P Hayden
Jan 30, 2010·Depression and Anxiety·Benedikt KlaukeKatharina Domschke
Mar 26, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Pia SoronenTiina Paunio
Feb 10, 2010·Depression and Anxiety·Hans-Ulrich WittchenMichelle G Craske
Jan 3, 2012·Behavioral and Brain Functions : BBF·Joanne VoiseyC Phillip Morris
Aug 30, 2011·Biological Psychiatry·John M HettemaEdwin J van den Oord
Apr 29, 2015·Biological Psychology·Jeanne E SavageRoxann Roberson-Nay
Feb 5, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Julia DiemerPeter Zwanzger
Dec 17, 2014·Psychopharmacology·Katharina DomschkePeter Zwanzger
Nov 1, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gul KaracetinIbrahim Balcioglu
Jan 15, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Borah KimSang-Hyuk Lee
Jan 29, 2013·Journal of Affective Disorders·Alex HatzimanolisNicholas C Stefanis
May 22, 2010·Psychiatry Research·Vandana ShashiThomas R Kwapil
Dec 3, 2014·Journal of Affective Disorders·Armen K GoenjianJulia N Bailey
Jun 28, 2016·Genetic Testing and Molecular Biomarkers·Charrlotte SeibDebra Anderson
Jul 16, 2016·International Journal of Methods in Psychiatric Research·Minyoung LeeJohn M Hettema
Oct 16, 2016·Brain Imaging and Behavior·Michelle N ServaasHarriëtte Riese

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

The International Journal of Neuropsychopharmacology
Katharina DomschkeJürgen Deckert
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Naomi R WrayN G Martin
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Katharina DomschkeStephen J Glatt
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Claudia RotheJames L Kennedy
© 2022 Meta ULC. All rights reserved