Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Eva KereszturiZsofia Nemoda

Abstract

Methylphenidate is the most frequently prescribed drug in the treatment of attention deficit hyperactivity disorder (ADHD) but it is not effective in every case. Therefore, identifying genetic and/or biological markers predicting drug-response is increasingly important. Here we present a case-control study and pharmacogenetic association analyses in ADHD investigating three dopaminergic polymorphisms. Previous studies suggested variable number of tandem repeats (VNTR) in the dopamine D4 receptor (DRD4) and the dopamine transporter (DAT1) genes as genetic risk factors for ADHD and as possible markers of methylphenidate response. Our results did not indicate substantial involvement of these two VNTRs in ADHD, however, both the case-control and the pharmacogenetic analyses showed significant role of the high activity Val-allele of cathecol-O-methyltransferase (COMT) Val158Met polymorphism in our ADHD population. The Val-allele was more frequent in the ADHD group (n = 173) compared to the healthy population (P = 0.016). The categorical analysis of 90 responders versus 32 non-responders showed an association between the Val-allele or Val/Val genotype and good methylphenidate response (P = 0.009 and P = 0.034, respectively). Analyzin...Continue Reading

References

Dec 22, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·B G Winsberg, D E Comings
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Venkata S MattayDaniel R Weinberger
Aug 5, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aiveen KirleyMichael Gill
Mar 31, 2004·Cancer Cell·Derek LeRoith, Lee Helman
Sep 15, 2004·European Child & Adolescent Psychiatry·Jan K BuitelaarUNKNOWN Stomoxetine International Study Group
Dec 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David C LottHarriet de Wit
Apr 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark A SteinEdwin H Cook
Jun 14, 2005·Biological Psychiatry·Stephen V FaraonePamela Sklar
Jun 14, 2005·Biological Psychiatry·James J McGough
Aug 6, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·K LangleyA Thapar
Sep 24, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Emma M van der MeulenJan K Buitelaar
Feb 16, 2006·Biological Psychiatry·Elizabeth M TunbridgeDaniel R Weinberger
Aug 19, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Eric MickPamela Sklar
Oct 26, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ridha JooberMarina Ter Stepanian
Nov 2, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Keun-Ah CheonSoo-Churl Cho
Dec 16, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Cristian Patrick ZeniLuis Augusto Rohde
Dec 16, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Eva KereszturiZsofia Nemoda
May 18, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Zsanett TarnokZsofia Nemoda
Jun 2, 2007·The American Journal of Psychiatry·Guilherme PolanczykLuis Augusto Rohde

❮ Previous
Next ❯

Citations

Jun 17, 2008·Der Nervenarzt·T J RennerK-P Lesch
Nov 12, 2010·European Journal of Clinical Pharmacology·Roberta RussoUNKNOWN TEDDY European Network of Excellence
May 23, 2012·Molecular Neurobiology·Jing WuLing-Qiang Zhu
Apr 24, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicolas RamozPhilip Gorwood
Dec 20, 2013·Journal of Child and Adolescent Psychopharmacology·Katherine A JohnsonZiarih Hawi
Mar 20, 2010·Pharmacogenomics·Christian KielingLuis Augusto Rohde
Apr 25, 2013·Genetics and Molecular Research : GMR·E ArmaganO Görükmez
Oct 10, 2014·Current Psychiatry Reports·Stephen V FaraoneCatia Scassellati
Jan 27, 2016·The Pharmacogenomics Journal·M PagerolsJ A Ramos-Quiroga
Oct 9, 2012·Child and Adolescent Psychiatric Clinics of North America·Christopher A WallBrett A Koplin
Dec 6, 2011·Brain Research Bulletin·A Veronica Witte, Agnes Flöel
Nov 4, 2015·Annual Review of Pharmacology and Toxicology·Sebastian C HolstHans-Peter Landolt
Sep 8, 2009·Neuropharmacology·Zsofia NemodaMaria Sasvari-Szekely
Sep 20, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H HallelandS Johansson
Sep 28, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Judith S NijmeijerPieter J Hoekstra
May 9, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Estela Maria BruxelLuis Augusto Rohde
Jul 21, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Matthew D AlbaughJames J Hudziak
Oct 26, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Tanya E FroehlichRobert S Kahn
May 19, 2009·Neuroscience·D Dickinson, B Elvevåg
Dec 15, 2010·Trends in Cognitive Sciences·Masud Husain, Mitul A Mehta
Apr 23, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Se-Hoon ShimYong-Ku Kim
Apr 29, 2016·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Onder OzturkHasan Herken
Jun 13, 2012·The Australian and New Zealand Journal of Psychiatry·Florence Levy
Nov 25, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robabeh SoleimaniMir Mohammad Jalali
Nov 29, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Darya NaumovaRidha Joober
Feb 19, 2015·Journal of Attention Disorders·Young Ho Lee, Gwan Gyu Song
Apr 6, 2019·Pharmacogenetics and Genomics·Tyler StevensTeri E Klein
May 8, 2020·Current Psychiatry Reports·Lisa B NamerowSalma Malik
Jan 13, 2018·Current Problems in Pediatric and Adolescent Health Care·Anna M WehryJeffrey R Strawn
Apr 3, 2021·Therapeutic Advances in Drug Safety·Aisling R Caffrey, Eric P Borrelli
Apr 8, 2021·Pediatric Research·Sonya C Tang GirdwoodLaura B Ramsey

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