Catechol-substituted phenoxypropanolamines: adrenoceptor activity in the anaesthetized cat

British Journal of Pharmacology
H DowdC Raper

Abstract

1 The pharmacological actions of racemic noradrenaline, adrenaline, isoprenaline and N-t-butylnoradrenaline have been compared with those of their corresponding derivatives containing an oxymethylene (OXY) link between the ring and ethanolamine side chain. 2 The compounds were tested in the anaesthetized cat for their ability to produce positive chronotropic effects, bronchodilator actions, changes in perfusion pressure in the perfused hind limb and decreases in soleus muscle contractions. 3 All the OXY-derivatives were potent beta-adrenoceptor agonists. The inclusion of the oxymethylene link promotes selectivity for beta1-as opposed to beta2-adrenoceptor activity. 4 In comparison with the parent compounds, the OXY-derivatives of adrenaline and noradrenaline had very weak alpha-adrenoceptor stimulant effects.

Citations

Jul 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·C MaccarroneC Raper
Nov 15, 1978·European Journal of Pharmacology·C RaperD Iakovidis
Dec 10, 1985·European Journal of Pharmacology·G A McPhersonC Raper
Jul 1, 1978·Clinical and Experimental Pharmacology & Physiology·G S KehH Dowd
May 1, 1980·Clinical and Experimental Pharmacology & Physiology·R G Goldie
May 1, 1980·The Journal of Pharmacy and Pharmacology·G A McPhersonC Raper
Apr 1, 1980·British Journal of Pharmacology·D IakovidisC Raper

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