Catecholamine and Indolamine Pathway: A Case-Control Study in Fibromyalgia

Biological Research for Nursing
Alma RusJosé Manuel Martínez-Martos

Abstract

Fibromyalgia (FM) is a complex syndrome characterized by widespread pain. Its etiology is unclear, and diagnosis is difficult. The aim of this study was to assess plasma levels of monoamine neurotransmitters (catecholamines, indolamines, and intermediate metabolites) in patients with FM and healthy controls to investigate possible alterations in the metabolism of these molecules in FM. We also examined potential relationships between monoamine neurotransmitters and clinical features of FM. The predictive value of these molecules in FM was determined by receiver operating characteristic analysis. We measured plasma catecholamines (epinephrine, norepinephrine, and dopamine), as well as indolamines and intermediary metabolites (serotonin or 5-hydroxytryptamine [5-HT], 5-hydroxyindolacetic acid [5-HIAA], 5-hydroxytryptophan [5-HTP], and N-acetyl-5-hydroxytryptamine [Nac-5-HT]) in 35 women with FM and 12 age-matched healthy women. Higher levels of norepinephrine and lower levels of dopamine, 5-HT, 5-HIAA, and 5-HTP were found in women with FM in comparison with controls. Epinephrine and Nac-5-HT levels did not differ significantly between groups. Higher norepinephrine levels were associated with worse physical health status in FM pa...Continue Reading

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Citations

Jan 19, 2019·Biological Research for Nursing·Francisco MolinaAlma Rus
Aug 15, 2019·Clinical and Translational Science·Victoria MenziesDebra E Lyon
Sep 30, 2020·Nursing Research·Alma RusMaria Jesus Alvarez-Cubero
Apr 14, 2020·Reumatología clinica·Diego Felipe García Rodríguez, Carlos Abud Mendoza
Jul 17, 2021·Neural Regeneration Research·Carlos Pereira MartinsRafael Cypriano Dutra

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Methods Mentioned

BETA
deamination

Software Mentioned

Power
MedCalc
TotalChrom WorkStation
SPSS Statistics

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