PMID: 6108565Oct 1, 1980Paper

Catecholamine biosynthetic enzymes are expressed in replicating cells of the peripheral but not the central nervous system

Proceedings of the National Academy of Sciences of the United States of America
T P RothmanD J Reis

Abstract

We sought to determine whether the precursors of catecholamine-containing neurons in the developing peripheral and central nervous systems of chickens and rats express the biosynthetic enzymes tyrosine hydroxylase [THase; tyrosine 3-monooxygenase; L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] or dopamine beta-hydroxylase [DBHase; 3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase (beta-hydroxylating), EC 1.14.17.1], prior to the time they withdraw from the cell cycle. Chicken embryos (stages 26-27) were injected with [3H-thymidine and 4 hr later were prepared for the simultaneous demonstration of radioautographically labeled nuclei in immunoreactive THase cells. The brains and sympathetic chains of rat fetuses (days E12-E14), exposed for 2 hr to [3H]thymidine, were treated similarly except that peripheral tissues were stained with a specific antibody to DBHase as well as anti-THase. In the peripheral nervous system of both chicken and rat, nuclei of THase-containing cells were radioautographically labeled. DBHase-containing cells in the peripheral nervous system of rats were also labeled and thus are noradrenergic. THase was localized in cells of the brain of the same rat fe...Continue Reading

References

Jul 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·V M PickelD J Reis
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G TeitelmanD J Reis
Jan 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·V M PickelD J Reis
Jun 1, 1977·Journal of Neurocytology·I A Hendry
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T H JohD Reis
Jan 1, 1972·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·L Olson, A Seiger
Aug 30, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Seiger, L Olson
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J C Eccles

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Citations

Jan 1, 1987·Cancer Metastasis Reviews·S R VandenbergL J Rubinstein
Sep 11, 1989·Brain Research·K M Guthrie, M Leon
Dec 1, 1982·Developmental Biology·D E Burstein, L A Greene
Dec 1, 1983·Developmental Biology·A KoulakoffY Berwald-Netter
May 1, 1990·Brain Research. Developmental Brain Research·D R Zhang, H H Yeh
Aug 20, 1993·Brain Research. Developmental Brain Research·D K Wu, C L Cepko
Jan 14, 1995·Brain Research. Developmental Brain Research·T TharakanM D Gershon
Jan 1, 1991·Trends in Neurosciences·A L Calof
Apr 1, 1992·Neurochemistry International·H RösnerH Rahmann
Apr 1, 1983·Brain Research Bulletin·J A Wallace, J M Lauder
Feb 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·W A Beresford
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E DiCicco-Bloom, I B Black
Jun 1, 1990·The Journal of Cell Biology·E DiCicco-BloomI B Black
Jan 1, 1990·The European Journal of Neuroscience·Hermann Rohrer
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alissa ArmstrongRejji Kuruvilla
Oct 9, 2007·Molecular and Cellular Neurosciences·Konstantina TsarovinaHermann Rohrer

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