May 28, 1976

Catecholamine enzymes in the degenerative neurological disease idiopathic orthostatic hypotension

Science
I B Black, C K Petito

Abstract

Discrete brain areas and sympathetic ganglia obtained at autopsy from patients with idiopathic orthostatic hypotension were assayed for tyrosine hydroxylase and dopamine beta-hydroxylase. Dopamine beta-hydroxylase activity was decreased 7.5-fold in sympathetic ganglia, while tyrosine hydroxylase activity was reduced more than 50-fold in the pontine nucleus locus coeruleus. These observations indicate that noradrenergic neurons of both brain and ganglion are affected in idiopathic orthostatic hypotension, but suggest that the central and peripheral biochemical deficits differ.

  • References
  • Citations21

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations21

Citations

Mentioned in this Paper

Idiopathic Orthostatic Hypotension
Abnormal Degeneration
Enzymes, antithrombotic
Catecholamine [EPC]
Autopsy
Brain
Synovial Cyst
Nerve Degeneration
Hypotension, Orthostatic
Substantia Nigra Structure

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.