Catecholamine excretion profiles identify clinical subgroups of neuroblastoma patients

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Iedan R N VerlyGodelieve A M Tytgat

Abstract

Analysis of urinary catecholamine metabolites is one of the primary modalities to diagnose patients with neuroblastoma. Although catecholamine excretion patterns have been recognised in the past, their biological rationale and clinical relevance remain largely unknown. Therefore, this study was designed to identify unique catecholamine excretion patterns and elucidate their underlying biology and clinical relevance. A panel of 25 neuroblastoma cell lines was screened for catecholamine excretion. Detection of the catecholamine enzymes was performed using Western blot. Based on catecholamine enzymes presence and excreted catecholamine metabolites, excretion profiles were defined. The prevalence of these profiles was investigated in vivo using diagnostic urines from 301 patients with neuroblastoma and immunohistochemistry on primary tumours. The clinical relevance of the profiles was determined by linking the profiles to clinical characteristics and outcome of patients with neuroblastoma. Four excretion profiles (A-D) were identified in vitro, which correlated with the relative protein expression of the catecholamine enzymes. These profiles were also identified in urine samples from patients with neuroblastoma and correlated with ...Continue Reading

Citations

May 24, 2020·The Journal of Applied Laboratory Medicine·Florette K Hazard, Hiroyuki Shimada
Feb 9, 2021·Journal of Chromatography. a·Jan LankelmaPaul J van der Sluis
Jan 28, 2022·JCO Precision Oncology·Iedan R N VerlyAndré B P van Kuilenburg

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