Catecholamine-induced opening of intrapulmonary arteriovenous anastomoses in healthy humans at rest

Journal of Applied Physiology
Steven S LaurieAndrew T Lovering


The mechanism or mechanisms that cause intrapulmonary arteriovenous anastomoses (IPAVA) to either open during exercise in subjects breathing room air and at rest when breathing hypoxic gas mixtures, or to close during exercise while breathing 100% oxygen, remain unknown. During conditions when IPAVA are open, plasma epinephrine (EPI) and dopamine (DA) concentrations both increase, potentially representing a common mechanism. The purpose of this study was to determine whether EPI or DA infusions open IPAVA in resting subjects breathing room air and, subsequently, 100% oxygen. We hypothesized that these catecholamine infusions would open IPAVA. We performed saline-contrast echocardiography in nine subjects without a patent foramen ovale before and during serial EPI and DA infusions while breathing room air and then while breathing 100% oxygen. Bubble scores (0-5) were assigned based on the number and spatial distribution of bubbles in the left ventricle. Pulmonary artery systolic pressure (PASP) was estimated using Doppler ultrasound, while cardiac output (Q(C)) was measured using echocardiography. Bubble scores were significantly greater during EPI infusions of 80-320 ng·kg(-1)·min(-1) compared with baseline when subjects breath...Continue Reading


Oct 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R J PorcelliE H Bergofsky
May 1, 1975·British Heart Journal·E L HollowayD C Harrison
Oct 1, 1991·The American Journal of Physiology·R S MazzeoJ T Reeves
Apr 1, 1989·Journal of Applied Physiology·L B RowellD R Seals
Jul 1, 1985·Journal of Applied Physiology·J A MaddenD R Harder
Apr 1, 1973·Journal of Applied Physiology·R J Porcelli, E H Bergofsky
Jan 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J L BerkM Rupright
Oct 1, 1973·Annals of Surgery·J L BerkS Nomoto
Feb 1, 1974·Archives of Surgery·S NomotoR Koo
Nov 1, 1969·British Journal of Pharmacology·D C HarrisonB U Wintroub
Aug 1, 1971·The American Journal of Physiology·F S Fay
May 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R GrahamH S Goldberg
Feb 1, 1996·Journal of the American College of Cardiology·W A HaqueL I Sinoway
Mar 1, 1996·The Journal of Surgical Research·D A FullertonR C McIntyre
May 13, 1998·Acta Physiologica Scandinavica·M Rostrup
Oct 21, 1998·Experimental Eye Research·Y ZhuJ M Gidday
Jun 1, 1953·Experientia·M SIRSI, K BUCHER
Jun 1, 1965·Circulation Research·J L MCNAYL I GOLDBERG
Jul 1, 1965·Clinical Radiology·F M ELLIOTT, L REID
Dec 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·C E TOBIN, M O ZARIQUIEY
Jul 1, 1951·The Journal of Clinical Investigation·A C WITHAM, J W FLEMING
Apr 27, 2004·Journal of Applied Physiology·Marlowe W EldridgeJohn S Hokanson
Sep 25, 2004·The Journal of Physiology·Michael K SticklandRichard L Jones
Aug 2, 2005·The European Respiratory Journal·M R MillerATS/ERS Task Force
Sep 2, 2005·The European Respiratory Journal·J WangerG Viegi
Oct 6, 2005·The European Respiratory Journal·N MacintyreJ Wanger
Oct 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Kerstin M OltmannsAchim Peters
Dec 17, 2005·American Journal of Respiratory Cell and Molecular Biology·Corinna BruecklWolfgang M Kuebler
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Andrew T LoveringMarlowe W Eldridge
Feb 23, 2008·Journal of Applied Physiology·Andrew T LoveringMarlowe W Eldridge
Aug 9, 2008·The Journal of Physiology·Andrew T LoveringMarlowe W Eldridge
Sep 4, 2008·Circulation·Christopher B Overgaard, Vladimír Dzavík
Jan 1, 1948·The American Journal of Physiology·M PRINZMETAL, E M ORNITZ
Aug 25, 2009·American Heart Journal·Hamish FarquharRichard Beasley
Sep 22, 2009·Metabolism: Clinical and Experimental·Karen R KellyJohn P Kirwan
Aug 7, 2010·Journal of Applied Physiology·Steven S LaurieAndrew T Lovering
Mar 17, 2012·Journal of Applied Physiology·Melissa L BatesMarlowe W Eldridge


Oct 29, 2013·Annals of the American Thoracic Society·Andrew T LoveringBernard Thébaud
Aug 31, 2013·Annals of the American Thoracic Society·Csaba GalambosSteven H Abman
Nov 25, 2014·American Journal of Respiratory and Critical Care Medicine·Claire L Shovlin
Jan 8, 2015·The Journal of Physiology·Andrew T LoveringJonathan E Elliott
Jan 25, 2016·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·J Novo MatosT Glaus
Feb 20, 2015·Echocardiography·David Michael McMullan, R Kirk Riemer
May 8, 2013·Respiratory Physiology & Neurobiology·Jonathan E ElliottAndrew T Lovering
May 9, 2015·The Journal of Physiology·Vincent TedjasaputraMichael K Stickland
Apr 22, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emily J BootherClaire L Shovlin
Aug 30, 2017·Respiration; International Review of Thoracic Diseases·Sophie Dupuis-GirodClaire L Shovlin
Nov 17, 2017·Thorax·Claire L ShovlinBritish Thoracic Society
Oct 3, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kaori OshimaMasahiko Oka
Mar 15, 2014·Journal of Applied Physiology·H Cameron NorrisAndrew T Lovering
Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christian Carl NorvikKarin Tran-Lundmark
Aug 27, 2019·The Journal of Physiology·Michael K SticklandSusan R Hopkins

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