PMID: 1057183May 1, 1975Paper

Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites

Proceedings of the National Academy of Sciences of the United States of America
C MukherjeeR J Lefkowitz

Abstract

Injection of frogs with beta-adrenergic catecholamines for 1-24 hr produces marked subsensitivity of the erythrocyte membrane adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); EC 4.6.1.1.] to in vitro stimulation by isoproterenol. The subsensitization is specific for catecholamine stimulation, since basal and fluoride-stimulated enzyme activity are unaffected. Maximum isoproterenol-stimulated adenylate cyclase activity declines by 75% in the isoproterenol-treated animals (P less than 0.001). The concentration of isoproterenol causing one-half maximal activation of adenylate cyclase, however, is unaltered. (-)[3H]Alprenolol, a potent competitive beta-adrenergic antagonist, was used to study directly the beta-adrenergic receptor binding sites in the erythrocyte membranes from control and subsensitized animals. A highly significant (P less than 0.005) 60% fall in the number of the beta-adrenergic receptor binding sites ("specific"(-)[3H]alprenolol binding sites) in the treated animals was found. The binding affinity of the sites was not markedly altered. These data suggest that beta-adrenergic catecholamines are able to regulate catecholamine sensitivity of tissues in vivo, by regulating the properties of the beta-adrenergic...Continue Reading

References

Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R W AlexanderR J Lefkowitz
Jun 28, 1974·Science·J Axelrod
Oct 29, 1971·Nature·R Miledi, L T Potter
Aug 1, 1973·Metabolism: Clinical and Experimental·J Roth
Aug 6, 1973·Biochemical and Biophysical Research Communications·I D GoldfineR W Bates
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J R GavinD N Buell
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T Deguchi, J Axelrod
Sep 23, 1974·Biochemical and Biophysical Research Communications·R J LefkowitzM G Caron
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·T Deguchi, J Axelrod
Apr 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J A ArcherJ Roth
Apr 12, 1974·Science·M Brownstein, J Axelrod
Apr 1, 1974·Analytical Biochemistry·Y SalomonM Rodbell
Jul 11, 1972·Biochemical and Biophysical Research Communications·C R KahnJ Roth
Feb 10, 1967·Annals of the New York Academy of Sciences·R F Furchgott

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Citations

Feb 1, 1979·Journal of Clinical Pharmacology·H BoudoulasG Dalamangas
Jun 1, 1996·Cardiovascular Drugs and Therapy·K A McKnightN S Dhalla
Aug 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·W H AndersonA Szentivanyi
May 1, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann, L Birnbaumer
May 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·S ShimaM Asakura
Dec 17, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·W KrawietzC Konrad
May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·G SchmidA Heidland
Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·A J SchreursF P Nijkamp
Jan 1, 1980·Archives of Gynecology·U MüllerJ W Siebers
May 10, 1979·Biochimica Et Biophysica Acta·S P Mukherjee, W S Lynn
Jan 26, 1976·Biochemical and Biophysical Research Communications·M G Caron, R J Lefkowitz
Aug 1, 1976·European Journal of Pharmacology·G K Terpstra, J A Raaijmakers
Aug 29, 1980·European Journal of Pharmacology·E B NielsenC Braestrup
Aug 27, 1981·European Journal of Pharmacology·J Ben-BarakY Dudai
May 20, 1983·European Journal of Pharmacology·Y NomuraT Segawa
Mar 16, 1984·European Journal of Pharmacology·M J Ward, D R Tomlinson
Nov 26, 1991·European Journal of Pharmacology·J T SullebargerC S Liang
May 25, 1987·Life Sciences·D Lichtstein, D Rodbard
Apr 1, 1979·Mechanisms of Ageing and Development·F C YinM L Weisfeldt
Apr 1, 1979·Prostaglandins·B CooperR I Handin
Jan 1, 1984·Prostaglandins·G C Di RenzoJ E Bleasdale

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