Catecholamine inotrope resuscitation of antibiotic-damaged staphylococci and its blockade by specific receptor antagonists

The Journal of Infectious Diseases
Primrose P E FreestoneMark Lyte

Abstract

The increasing use of antibiotic-coated catheters, such as those containing rifampin or minocycline, has led to a decrease in catheter colonization by staphylococci but not to a decrease in the incidence of catheter-related bloodstream infection (BSI). Because catheters are used for the administration of catecholamine inotropes to maintain cardiac function, we examined whether 2 commonly employed inotropes, dopamine and norepinephrine, could affect bacterial viability after exposure to rifampin and minocycline. Rifampin inhibition and minocycline inhibition of staphylococcal growth could be reversed by exposure to dopamine or norepinephrine as a result, in part, of catecholamine-mediated increased provision of host-sequestered iron. The simultaneous addition of inotropes with an antibiotic did not affect antibiotic susceptibility. Inotrope-induced growth in bacteria previously exposed to antibiotics was blocked by the inclusion in culture media of specific catecholamine-receptor antagonists. Considered collectively, these results provide a mechanistic basis for understanding how host-related factors, such as inotrope-based therapeutics, may influence the recovery of antibiotic-stressed bacteria in clinical settings.

References

Jan 1, 1992·Life Sciences·M Lyte, S Ernst
Aug 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E Rupp, G L Archer
Aug 26, 1998·Biochemical and Biophysical Research Communications·V CoulangesD J Vidon
Jan 8, 1999·The New England Journal of Medicine·R O DarouicheG Mayhall
Mar 18, 1999·FEMS Microbiology Letters·P P FreestoneM Lyte
Mar 26, 1999·Microbial Pathogenesis·K S KinneyG Sonnenfeld
Nov 28, 2001·Current Infectious Disease Reports·Christopher J. Crnich, Dennis G. Maki
Jan 5, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L A SampathS M Modak
Apr 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher J Crnich, Dennis G Maki
Jun 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott A McConnellElias J Anaissie
Sep 12, 2003·Trends in Pharmacological Sciences·Clare BergsonMichael S Lidow
Jan 1, 2004·Trends in Microbiology·Mark Lyte
Apr 9, 2004·The New England Journal of Medicine·Rabih O Darouiche
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher J Crnich, Dennis G Maki
Aug 5, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christopher J Crnich, Dennis G Maki
Jul 6, 2006·Applied and Environmental Microbiology·Phyllis M O'DonnellGerald Sonnenfeld
Aug 3, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J J Ruhe, A Menon

❮ Previous
Next ❯

Citations

Jan 2, 2014·Scientifica·Primrose Freestone
Feb 14, 2016·Intensive Care Medicine·Davide Tommaso Andreis, Mervyn Singer
Oct 4, 2011·Veterinary Microbiology·Elin VerbruggheFrank Pasmans
Mar 21, 2015·The Journal of Endocrinology·Sara SandriniPrimrose Freestone
May 20, 2008·Advances in Applied Microbiology·Primrose P E Freestone, Mark Lyte
May 28, 2019·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Marwh AldriweshPrimrose Freestone
Sep 16, 2017·Shock·Clair HartmannBenedikt Nußbaum
Oct 17, 2017·Cellular and Molecular Life Sciences : CMLS·Aurelia SantoroClaudio Franceschi
Nov 20, 2020·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Sara Zaher
May 27, 2016·Microbiology Spectrum·Mark Lyte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Cellulitis

Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. Discover the latest research on cellulitis here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.