PMID: 42151Nov 24, 1979

Catecholamine-mediated arrhythmias in acute myocardial infarction. Experimental evidence and role of beta-adrenoceptor blockade

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
L H Opie, W F Lubbe


Ventricular fibrillation is a major mechanism of sudden death. The cellular link between catecholamine activity and the development of serious ventricular arrhythmias may be in the formation of cyclic adenosine monophosphate (cAMP). Cyclic AMP and agents promoting cAMP accumulation allow development of slow responses which, especially in the presence of regional ischaemia, could develop into ventricular fibrillation. The role of beta-antagonist agents in the therapy of acute myocardial infarction is analysed in relation to the hypothesis linking cAMP and ventricular fibrillation. Reasons for the limited effectiveness of anti-arrhythmic therapy with beta-antagonist agents are given.

Related Concepts

Ventricular Fibrillation
Depression, Chemical
Catecholamine [EPC]
Left Ventricular Structure
Antagonist Muscle Action
Anti-Arrhythmia Agents
Cyclic AMP

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