PMID: 1214228Dec 1, 1975Paper

Catecholamine release from bovine adrenal medulla in response to maintained depolarization

The Journal of Physiology
P F Baker, T J Rink

Abstract

Prolonged exposure of venous-perfused bovine adrenal glands to high K in the presence of external Ca produces a transient increase in catecholamine output that reaches a maximum after about 1 min and then declines with a half-time of about 1-2 min. 2. The time course of the transient secretory response to high K does not depend appreciably on the total catecholamine output which indicates that depletion of releasable catecholamine is unlikely to be responsible for the transient nature of the response. 3. Application of 3-6 mM-Ba stimulates secretion from a gland after many minutes exposure to high K, when catecholamine output has declined close to resting levels. This provides further evidence that depletion does not play a major role in the transient response and shows that maintained depolarization does not inhibit the secretory mechanism. 4. Exposure to high K solutions in which Ca has been replaced isomotically by Mg does not evoke any catecholamine output. Subsequent application of Ca always elicits some secretion although the size of this response to added Ca declines rapidly during exposure to Ca-free, high K solutions. The failure of the secretory response in these experiments is more rapid, and earlier in onset than th...Continue Reading

Citations

Jul 1, 1988·The Journal of Membrane Biology·D E Knight
Aug 6, 2000·British Journal of Pharmacology·J JordánV Ceña
Apr 1, 1983·Archives internationales de physiologie et de biochimie·J E PintoA E Domínguez
Oct 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M M SalemD C Batlle
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May 23, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D E Knight, N T Kesteven
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