Catecholamine release mediates pressor effects of adrenomedullin-(15-22) in the rat

Hypertension
H C ChampionP J Kadowitz

Abstract

Human adrenomedullin, a novel hypotensive peptide, contains a six-member ring structure similar to that found in calcitonin gene-related peptide and pancreatic amylin. Unlike the full-sequence peptide, human adrenomedullin-(15-22) [hADM-(15-22)], which contains the ring structure, increases systemic arterial pressure in the rat but not the cat. We undertook the present study to investigate the mechanism by which hADM-(15-22) increases systemic arterial pressure in the rat. Injection of hADM-(15-22) in doses of 10 to 300 nmol/kg i.v. increased systemic arterial pressure in a dose-dependent manner and was threefold less potent than norepinephrine when doses were compared on a nanomole basis. However, the ring structures of human calcitonin gene-related peptide and human amylin, human calcitonin gene-related peptide-(1-8) and human amylin-(1-8), respectively, had no significant effect on systemic arterial pressure in the rat. Pressor responses to hADM-(15-22) were reduced significantly after administration of phentolamine or reserpine. Responses to hADM-(15-22) were not altered by the angiotensin type 1 blocking agent DuP 753 or the endothelin-A/endothelin-B receptor blocking agent bosentan, and responses to hADM-(15-22) and the n...Continue Reading

References

Oct 13, 1995·Biochemical and Biophysical Research Communications·H ShojiH Matsuo
Aug 1, 1995·British Journal of Pharmacology·A M ElhawaryC C Pang
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R R WhitesellJ M May
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M K BaskayaK Sugita
Feb 1, 1995·British Journal of Pharmacology·S M GardinerT Bennett
Jul 21, 1994·European Journal of Pharmacology·B LinH Lippton
Apr 15, 1994·Biochemical and Biophysical Research Communications·Y IshizakaT Eto
Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Feb 6, 1996·Biochemical and Biophysical Research Communications·T X WatanabeS Sakakibara
Jan 1, 1996·The American Journal of Physiology·E D KwonM B Burg

❮ Previous
Next ❯

Citations

Mar 14, 2000·Life Sciences·M Jougasaki, J C Burnett
Dec 10, 1999·Regulatory Peptides·H C ChampionP J Kadowitz
Apr 20, 2001·Journal of Chemical Neuroanatomy·M MuñozA González
Jul 16, 1999·Clinical and Experimental Pharmacology & Physiology·T IshimitsuH Matsuoka
Aug 24, 2002·Biology of Reproduction·Andrea G WitlinChandrasekhar Yallampalli
Jan 21, 2011·Physiological Reviews·Donald E KohanDavid M Pollock
Jan 15, 1999·Endocrine Research·A S BelloniG G Nussdorfer
Jul 18, 2001·Microscopy Research and Technique·M MuñozA González
Feb 6, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Ria SchönauerAnnette G Beck-Sickinger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.