PMID: 6105010Sep 8, 1980

Catecholamine synthesizing enzymes in the hypothalamus during the estrous cycle

Brain Research
L A Carr, J L Voogt

Abstract

The activities of tyrosine hydroxylase and dopamine-beta-hydroxylase were measured in the medial basal hypothalamus and remaining hyothalamic tissue of female rats at various times during diestrus 2, proestrus and estrus. Tyrosine hydroxylase activity in the medial basal hypothalamus was significantly lower at 12.00 h compared with other times on proestrus. This decrease preceded the elevation of serum prolactin and LH during the afternoon of proestrus. Tyrosine hydroxylase activity did not change significantly during diestrus 2 or estrus nor was it altered at any time in the remainder of the hypothalamus. Dopamine-beta-hydroxylase activity in the basal medial hypothalamus was significantly elevated at 12.00 h on proestrus and at 14.00 h on diestrus. The results provide further evidence for a decrease in dopaminergic neuron activity in the medial basal hypothalamus which may precipitate the series of events leading to the LH surge during proestrus. The increase in dopamine-beta-hydroxylase activity suggests that an increase in noradrenergic neuron activity may also be involved in triggering the release of LH.

References

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Citations

Dec 1, 1977·Pharmacology, Biochemistry, and Behavior·C D WiseL Stein
Apr 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·P Langelier, S M McCann
Aug 1, 1977·Endocrinology·J F Wiggins, J D Fernstrom
Jul 16, 1976·Brain Research·S R Chiocchio, M A Cannata
Jul 1, 1975·Pharmacology, Biochemistry, and Behavior·C W SimpsonL V Dicara
May 1, 1970·Endocrinology·H P Schneider, S M McCann
Sep 1, 1973·Endocrinology·E R SmithJ M Davidson
Dec 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·A O Donoso, M B De Gutierrez Moyano
Jul 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·G D NiswenderL E Reichert
Mar 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·G D NiswenderS Ellis

Related Concepts

Dbh
Enzymes, antithrombotic
Catecholamine [EPC]
Organum Vasculosum Laminae Terminalis
Luteozyman
Estrous Cycle
Estrus (fly)
Dopamine-beta-monooxygenase
Noradrenergic Neurons
Enzymes for Treatment of Wounds and Ulcers

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