PMID: 6105010Sep 8, 1980Paper

Catecholamine synthesizing enzymes in the hypothalamus during the estrous cycle

Brain Research
L A Carr, J L Voogt

Abstract

The activities of tyrosine hydroxylase and dopamine-beta-hydroxylase were measured in the medial basal hypothalamus and remaining hyothalamic tissue of female rats at various times during diestrus 2, proestrus and estrus. Tyrosine hydroxylase activity in the medial basal hypothalamus was significantly lower at 12.00 h compared with other times on proestrus. This decrease preceded the elevation of serum prolactin and LH during the afternoon of proestrus. Tyrosine hydroxylase activity did not change significantly during diestrus 2 or estrus nor was it altered at any time in the remainder of the hypothalamus. Dopamine-beta-hydroxylase activity in the basal medial hypothalamus was significantly elevated at 12.00 h on proestrus and at 14.00 h on diestrus. The results provide further evidence for a decrease in dopaminergic neuron activity in the medial basal hypothalamus which may precipitate the series of events leading to the LH surge during proestrus. The increase in dopamine-beta-hydroxylase activity suggests that an increase in noradrenergic neuron activity may also be involved in triggering the release of LH.

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Citations

Oct 1, 1990·Neurochemical Research·J GlaserJ J Taljaard
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·P H DesanS F Maier
Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Apr 1, 1984·Brain Research Bulletin·K J RennerD M Quadagno
Aug 27, 1998·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·R StephensonJ Freeman
Jan 1, 1992·International Journal of Technology Assessment in Health Care·C J Partridge
Apr 24, 2014·The Cochrane Database of Systematic Reviews·Alex PollockPeter Langhorne
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Jul 19, 2001·Annals of the New York Academy of Sciences·V Quiñones-JenabS Jenab

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