PMID: 41908Nov 1, 1979

Catecholamine uptake blockade in anaesthetized dogs: influence on cardiovascular responses

The Journal of Pharmacy and Pharmacology
R A BrownJ Wilson

Abstract

The effects of differential and combined catecholamine uptake antagonism on cardiovascular responses of anaesthetized dogs to isoprenaline, noradrenaline, and electrical stimulation of the left ansa subclavia nerve have been studied. Uptake1 inhibition by cocaine HCl (5 mg kg-1 and 1 mg kg-1 every 45 min) enhanced responses to noradrenaline (0.1 to 2.0 micrograms kg-1 i.v.) and sympathetic nerve stimulation (1 to 20 Hz), but did not affect those to isoprenaline. Uptake2 inhibition by metanephrine (40 micrograms kg-1 min-1) enhanced cardiac responses to isoprenaline (0.05 to 1.0 microgram kg-1 i.v.), but did not significantly alter those to noradrenaline or nerve stimulation. Responses to all agonist interventions were increased by the combined administration of cocaine and metanephrine. Cocaine preferentially enhanced the positive chronotropic cardiac response to noradrenaline, but metanephrine did not differentiate between heart rate and contractility. These results have been discussed in the light of the mechanism of drug action involved.

References

Feb 1, 1989·Journal of the Autonomic Nervous System·A M BhatM N Levy
Oct 1, 1987·British Journal of Pharmacology·P D MitchellP A West

Citations

Feb 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·S Guimarães, M Q Paiva
May 1, 1975·Clinical and Experimental Pharmacology & Physiology·G M Picken, B Jarrott
Jun 1, 1975·The American Journal of Physiology·S KalsnerG M Smith
Jul 15, 1974·Biochemical Pharmacology·L L Iversen
Apr 1, 1971·British Journal of Pharmacology·L L Iversen
Nov 1, 1969·British Journal of Pharmacology·S L Lightman, L L Iversen
Jan 1, 1971·Cardiovascular Research·N S NejadB Lown
Apr 1, 1971·The Journal of Physiology·C M FurnivalH M Snow
Jul 1, 1969·British Journal of Pharmacology·S Kalsner
Aug 1, 1965·British Journal of Pharmacology and Chemotherapy·A S Burgen, L L Iversen

Related Concepts

Myocardial Contraction
Depression, Chemical
Sympathetic Nerve Structure
Diastolic Blood Pressure
Entire Sympathetic Nerve
Anesthesia Procedures
Cocaine
Norepinephrine
Norepinephrine Measurement
Drug Interactions

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