Catecholaminergic control of alpha-melanocyte-stimulating hormone (alpha MSH) release by frog neurointermediate lobe in vitro: evidence for direct stimulation of alpha MSH release by thyrotropin-releasing hormone

Endocrinology
M C TononH Vaudry

Abstract

The role of dopaminergic and adrenergic innervation of the intermediate lobe of amphibian pituitary in the release of alpha MSH has been studied in vitro. Neurointermediate lobes of frog (Rana ridibunda Pallas) have been perifused in amphibian culture medium (ACM) for 5-7 h. alpha MSH released in the effluent perifusate was measured by means of a sensitive and specific RIA. No significant morphological alteration of neurointermediate lobe cells was observed during the perifusion experiment, even at the electron microscopic level. The existence of dopaminergic receptors, responsible for an inhibition of frog melanotrophs, was shown using the dopaminergic agonists apomorphine (10(-6) M) and bromo-2-ergocryptine (10(-8) and 10(-7) M), which initiated a marked reduction of alpha MSH secretion. The effect of apomorphine was obliterated by the dopaminergic antagonist haloperidol. Haloperidol itself induced a dose-related stimulation, and the monoamine oxidase inhibitor nialamide (4 x 10(-3) M) inhibited alpha MSH secretion. In addition, haloperidol led to a complete reversal of the inhibitory effect of nialamide on alpha MSH secretion. These results demonstrate the existence, in the parenchyme of the intermediate lobe, of dopaminergi...Continue Reading

Citations

Jan 1, 1990·Journal of Neural Transmission. General Section·V SimonneauxP Pévet
Jan 1, 1987·Peptides·B M Verburg-van KemenadeH Vaudry
Jul 3, 2002·General and Comparative Endocrinology·E W RoubosB G Jenks
Aug 6, 2002·General and Comparative Endocrinology·J R LiesteB G Jenks
Dec 24, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·E W Roubos
Feb 26, 2000·Journal of Neuroendocrinology·H CastelH Vaudry
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N ChartrelH Vaudry
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·A MorP Nicolas
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·M GarnierH Vaudry
Jan 1, 1990·Fundamental & Clinical Pharmacology·J M DangerH Vaudry
Jun 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M LamaczH Vaudry
Jan 1, 1989·Annals of the New York Academy of Sciences·R J Guiloff
Jan 1, 1990·Annals of the New York Academy of Sciences·J M DangerH Vaudry
May 31, 1993·Annals of the New York Academy of Sciences·M C TononH Vaudry
May 14, 2009·General and Comparative Endocrinology·Ludovic GalasHubert Vaudry
Oct 1, 1989·General and Comparative Endocrinology·I D van ZoestB G Jenks
Dec 5, 2013·Biological Reviews of the Cambridge Philosophical Society·Iain S HaslamRalf Paus

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