Catecholaminergic drugs in chronic schizophrenia

Neuropsychobiology
F BrambillaA Guastalla

Abstract

The effect of dopaminergic-related and stimulatory drugs have been studied in chronic hebephrenic schizophrenics untreated with neuroleptic drugs. 6 patients received therapy of 2 g L-dopa + 200 mg carbodopa per day orally for 30 days, then placebo for 30 days. Following that 3 of the same patients received therapy of 2 g L-dopa + 200 mg carbodopa + 300 mg imipramine orally for 30 days, then placebo for 30 days. Following that the same 3 patients received 1 mg apomorphine s.c. for 15 days, then placebo for 15 days, then 1 mg apomorphine s.c. + 2 g L-dopa + 200 mg carbodopa per os daily for 15 days, then placebo for 15 days. The patients were examined psychologically by the Wittenborn Rating Scale, the Weigl Object-Sorting Test, and tests for verbal learning and verbal association, before and after each therapeutic trial. Levels of FSH, LH, testosterone and GH were assayed radioimmunologically before, in the middle of and after each course of therapy. 2 patients showed improvement in the affective-behavioural symptomatology during therapy, while the other 4, who had a more severe degree of mental deterioration and destruction, were unchanged. FSH and LH levels, very low under basal conditions, did not change under therapy. Testo...Continue Reading

Citations

Jan 1, 1981·Psychoneuroendocrinology·H Y MeltzerV S Fang
Jan 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·O BenkertH Wetzel
Jul 1, 1981·Clinical Toxicology·W J DeckerH F Combs
Oct 1, 1981·Journal of Pharmaceutical Sciences·R V SmithW H Riffee
Jul 20, 2007·The Cochrane Database of Systematic Reviews·A Elias, A Kumar

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