Catecholaminergic mechanisms of the lateral hypothalamus: their role in the mediation of amphetamine anorexia.

Brain Research
S F Leibowitz

Abstract

The brain mechanisms mediating amphetamine's suppressive effect on feeding behavior were analyzed in rats with chronically implanted brain cannulas. Experiments in which drugs were injected directly into the anterolateral hypothalamus, the region found to be most responsive to amphetamine's action, yielded the following results. (1) Over a dose range of 6.25 nmoles (0.8 mug) to 400 nmoles (51.4 mug), hypothalamically injected D-amphetamine produced a reliable suppression of food consumption (20 percent at 6.25 nmoles, increasing to 88 percent at 200 nmoles) and was found to be approximately 3 times as potent as L-amphetamine in yielding this effect. (2) The anorexic effect of hypothalamically injected D-amphetamine was totally abolished by local administration of alpha-methyltyrosine, an inhibitor of dopamine, norepinephrine, and perhaps epinephrine synthesis, or by local administration of Fla-63, an inhibitor of only norepinephrine, and perhaps epinephrine, synthesis. (3) This effect of hypothalamic D-amphetamine was also antagonized by locally administered dopaminergic or beta-adrenergic receptor blockers but was unaffected by alpha-adrenergic, serotonergic, and cholinergic blockers. (4) Lateral hypothalamic administration of...Continue Reading

References

Jan 1, 1975·Pharmacology, Biochemistry, and Behavior·I S SanghviS Gershon
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·L O Farnebo
Nov 1, 1973·The Journal of Pharmacy and Pharmacology·F BarzaghiE E Müller
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Mar 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M J BessonJ Glowinski
Oct 1, 1970·Journal of Comparative and Physiological Psychology·D L Margules
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·S F Leibowitz
Nov 1, 1971·British Journal of Pharmacology·D A Hutchins, K J Rogers
Nov 14, 1973·Nature: New Biology·Z L Kruk
Apr 1, 1974·The Journal of Comparative Neurology·O LindvallU Stenevi
Oct 1, 1969·The American Journal of Physiology·G P Smith, A N Epstein
Feb 1, 1970·Physiology & Behavior·R J Carey, A P Salim
Apr 1, 1966·Journal of Comparative and Physiological Psychology·S O Cole
Oct 28, 1966·Science·R A Levitt, A E Fisher
Jun 25, 1966·Nature·R Howe, R G Shanks

❮ Previous
Next ❯

Citations

Sep 2, 1983·European Journal of Pharmacology·C BendottiR Samanin
May 1, 1983·Physiology & Behavior·R F DaviesA J Zolovick
Feb 1, 1978·Pharmacology, Biochemistry, and Behavior·S F Leibowitz
Feb 1, 1980·Pharmacology, Biochemistry, and Behavior·J A GrinkerH Kissileff
Aug 1, 1982·Pharmacology, Biochemistry, and Behavior·P Willner, A Towell
Jan 1, 1985·Pharmacology, Biochemistry, and Behavior·A TowellD A Booth
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·J T McCabeS F Leibowitz
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·M A ParadaB G Hoebel
Mar 1, 1989·Pharmacology, Biochemistry, and Behavior·R A WiseL M Colle
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·P J Wellman, R Cockroft
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·P J Wellman
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·M BerlanP Montastruc
May 1, 1993·Pharmacology, Biochemistry, and Behavior·T BaptistaL Hernández
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·L Parker, K Leeb
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Jan 1, 1987·Pharmacology & Therapeutics·M F Sugrue
Jun 1, 1985·Brain Research·G L Willis, G C Smith
Nov 1, 1986·Brain Research Bulletin·S F LeibowitzJ A Grinker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.