Catecholaminergic Modulation of Conflict Control Depends on the Source of Conflicts

The International Journal of Neuropsychopharmacology
Wiebke BensmannChristian Beste

Abstract

To display goal-directed behavior, we must be able to resolve response conflicts that arise from processing various distractors. Such conflicts may be triggered by different kinds of distractor stimuli (e.g., priming and flanker stimuli), but it has remained largely unclear whether the functional and neurobiological underpinnings of both conflict types differ. We therefore investigated the functional relevance of the catecholamines dopamine and norepinephrine, which have been shown to increase the signal-to-noise ratio in neuronal processing and should therefore modulate response conflicts. In a double-blind, randomized, placebo-controlled study design, we examined the effect of methylphenidate (0.5 mg/kg) on both flanker-induced and priming-induced response conflicts in a group of n=25 healthy young adults. We used EEG recordings to examine event-related potentials in combination with source localization analyses to identify the cognitive-neurophysiological subprocesses and functional neuroanatomical structures modulated by methylphenidate. Compared with placebo, methylphenidate decreased flanker conflicts. This was matched by increased congruency effects in the fronto-central N2/P3 event-related potential complex and associat...Continue Reading

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Citations

Feb 28, 2019·Journal of Neurophysiology·Maik PertermannChristian Beste
Oct 28, 2019·Human Brain Mapping·Julia Friedrich, Christian Beste
Nov 9, 2019·The International Journal of Neuropsychopharmacology·Moritz MückschelChristian Beste
Jul 31, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lorenza S ColzatoChristian Beste
Dec 6, 2019·Frontiers in Psychiatry·Wiebke BensmannAnn-Kathrin Stock
Mar 11, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Witold X Chmielewski, Christian Beste
Jul 28, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Carl A RobertsCatharine Montgomery
Sep 11, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Franziska GillerChristian Beste

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