Catecholaminergic signalling through thymic nerve fibres, thymocytes and stromal cells is dependent on both circulating and locally synthesized glucocorticoids

Experimental Physiology
I PilipovićG Leposavić

Abstract

Glucocorticoids have been shown to modulate the expression of noradrenaline metabolizing enzymes and β(2)- and α(1B)-adrenoceptors in a tissue- and cell- specific manner. In the thymus, apart from extensive sympathetic innervation, a regulatory network has been identified that encompasses catecholamine-containing non-lymphoid and lymphoid cells. We examined a putative role of adrenal- and thymus-derived glucocorticoids in modulation of rat thymic noradrenaline levels and adrenoceptor expression. Seven days postadrenalectomy, the thymic levels of mRNAs encoding tyrosine hydroxylase, dopamine β-hydroxylase, monoamine oxidase-A and, consequently, noradrenaline were decreased. Catecholamine content was diminished in autofluorescent nerve fibres (judging by the intensity of fluorescence) and thymocytes (considering HPLC measurements of noradrenaline and the frequency of tyrosine hydroxylase-positive cells), while it remained unaltered in non-lymphoid autofluorescent cells. In addition, adrenalectomy diminished the thymocyte expression of β(2)- and α(1B)-adrenoceptors at both mRNA and protein levels. Administration of ketoconazole (an inhibitor of glucocorticoid synthesis/action; 25 mg kg(-1) day(-1), s.c.) to glucocorticoid-deprived...Continue Reading

References

Apr 25, 1977·Biochemical and Biophysical Research Communications·K NagaiahG Guroff
Mar 4, 1992·JAMA : the Journal of the American Medical Association·G P Chrousos, P W Gold
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L Aloe
Jan 1, 1997·Chemical Immunology·D A Weigent, J E Blalock
Jul 28, 1999·International Immunology·R SacedónA G Zapata
Dec 14, 2002·Brain, Behavior, and Immunity·Annemieke Kavelaars
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael DeuschleIsabella Heuser
Apr 1, 1997·Seminars in Cell & Developmental Biology·E L Sabban
Dec 15, 2004·The Journal of Experimental Medicine·Igor CimaThomas Brunner
Jun 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irini ManoliMarc R Blackman
Oct 27, 2005·Journal of Biochemistry and Molecular Biology·Heekyoung ChungRho H Seong
May 27, 2006·The Journal of Biological Chemistry·Xiao-Ming OuJean C Shih
Jul 18, 2006·Autonomic Neuroscience : Basic & Clinical·R Nicholas TrotterMargo R Roberts
Feb 12, 2008·Journal of Neuroimmunology·Ivan PilipovićGordana Leposavić
Apr 4, 2009·Physiological Reviews·Richard KvetnanskyMiklos Palkovits
Jun 24, 2009·Experimental Biology and Medicine·Zorica Stojić-VukanićGordana Leposavić
Nov 13, 2009·Immunobiology·Ferenc BoldizsarTimea Berki
Apr 20, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I PilipovićG Leposavi
Apr 2, 2011·Rejuvenation Research·Gergely TalaberJudit E Pongracz
May 5, 2011·American Journal of Physiology. Endocrinology and Metabolism·Matthew D TavesKiran K Soma
Sep 24, 2011·Journal of Neuroimmunology·Katarina RadojevićGordana Leposavić

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Citations

Jun 6, 2015·Scientific Reports·Benjamin MajorFulvio D'Acquisto
Nov 2, 2012·Experimental Physiology·Valdo José Dias da Silva, Julian F R Paton
Jan 19, 2018·Journal of Leukocyte Biology·Alyce J NichollsConnie H Y Wong
Feb 3, 2021·Animals : an Open Access Journal From MDPI·Mirosław KarpińskiMagdalena Krauze

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